DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marf1 and MARF1

DIOPT Version :9

Sequence 1:	NP_001246133.1	Gene:	Marf1 / 49895	FlyBaseID:	FBgn0039972	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_005255761.1	Gene:	MARF1 / 9665	HGNCID:	29562	Length:	1743	Species:	Homo sapiens

Alignment Length:	1194	Identity:	297/1194 - (24%)
Similarity:	515/1194 - (43%)	Gaps:	266/1194 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 QQLSTLSPTTALYSNFN------NSLEAGTAERLRL-NKTGSQVHSLYVGDGQVQNASEPLSFPS 100
            :|.|:...|....|..|      |:......|..|: :|||.:       :.:.|.....|..|:
Human   621 EQSSSAKATPGKGSQANSGSATKNTNVKSLQELCRMESKTGHR-------NSEHQQGHLRLVVPT 678

  Fly   101 HLNLYQYVRTPANFTINSRNRYIPYYNNRSYSASTTGFPIASTPLISSHAHIQDQQGAASYQTIV 165
            |.|....|.||.|..:..     |.|.......:.:...:.|:|:     ..:|::... :|...
Human   679 HGNSSAAVSTPKNSGVAE-----PVYKTSQKKENLSARSVTSSPV-----EKKDKEETV-FQVSY 732

  Fly   166 PLYQTASHCAQQHTTLASVAPIVDNSFVESTTCPMAGITSHNIKMKMIPPNVLLPCSRPTTTAVT 230
            |...:....::|      |:|::.:....|:              :.:.||:|   :|.:..|..
Human   733 PSAFSKLVASRQ------VSPLLASQSWSSS--------------RSMSPNLL---NRASPLAFN 774

  Fly   231 IQRSTGE-DGGDKEGHTFAKITEMSDAVTLQITNLDYSLDESHIRSFLLN-----------QLKP 283
            |..|:.| |..|          ..::...:|::|:||.|....::..|..           :|.|
Human   775 IANSSSEADCPD----------PFANGADVQVSNIDYRLSRKELQQLLQEAFARHGKVKSVELSP 829

  Fly   284 ITPVVSLVFEGSSYAKVTVPDLYFAKQVVSNLHRKKIGHKRMLVSYTRDSSLTEVNTLRCQVAGL 348
            .|       :....|.|.:.:|..|...|::|||.|||.|::|||....::...::.|..:...:
Human   830 HT-------DYQLKAVVQMENLQDAIGAVNSLHRYKIGSKKILVSLATGAASKSLSLLSAETMSV 887

  Fly   349 LKDVPFNTLPMYKFRELFQSRFKTSISVLDLYKMQDICTINSDNNEEKFISLNPELV-------- 405
            |:|.|...||::||.::::.:|...::|.||||:.|...|....| .:.:.|.|...
Human   888 LQDAPACCLPLFKFTDIYEKKFGHKLNVSDLYKLTDTVAIREQGN-GRLVCLLPSSQARQSPLGS 951

  Fly   406 ------NTLDISPLM-EGLQHSVPYCSIHFKKEQHKGWAEQEIEP----LPNVFMSISEIQKLIY 459
                  ::.:.||:: |.|::..|.|..|.   .:|.::|.|.:|    :|.|.:|:......::
Human   952 SQSHDGSSTNCSPIIFEELEYHEPVCRQHC---SNKDFSEHEFDPDSYKIPFVILSLKTFAPQVH 1013

  Fly   460 PLLKVHTGDIPVATLLHCVKEE---LNVSIMANENGVNLEHLICCVQGIQVRANNFGIKILGWLE 521
            .||:.|.|.:|:.:...|...|   |.| :..|:.||.|||.|.||.|:.:.....|||::.|:.
Human  1014 SLLQTHEGTVPLLSFPDCYIAEFGDLEV-VQENQGGVPLEHFITCVPGVNIATAQNGIKVVKWIH 1077

  Fly   522 INKEMQSGTFNASSNTCSLTASDRTNCGSYFKNSVADP-LFQISREVIELLKMSPKSTMKFNRFI 585
             ||.....|             |.....|  |:.|.:| |.|.|||||:|||..|...:..:.||
Human  1078 -NKPPPPNT-------------DPWLLRS--KSPVGNPQLIQFSREVIDLLKSQPSCVIPISHFI 1126

  Fly   586 PAYHNHFGKQCRVADYGYTKLIELFEALSNVVQIMGDGENRQITLSHRIQIRRFTSDLLRVLRAN 650
            |:||:||.|||||:||||:|||||.||:.:|:||:|.|..|.:||:||.|::|||.|||::|::.
Human  1127 PSYHHHFAKQCRVSDYGYSKLIELLEAVPHVLQILGMGSKRLLTLTHRAQVKRFTQDLLKLLKSQ 1191

  Fly   651 GNNSVLLSQLPLVFTQTQNKTFDITDYGVCDLIDILDGLVSSNIVTLGAAQNGKDILISMPKRKQ 715
            .:..|::.:....:....:|.:|:|:||||:||||:..:..:   |:..:|...:::|.:|||::
Human  1192 ASKQVIVREFSQAYHWCFSKDWDVTEYGVCELIDIVSEIPDT---TICLSQQDNEMVICIPKRER 1253

  Fly   716 TNSELEKTCVFAGEMVELFQNALQYTILFQKFVRSYHYHFAYQCRLSDYGFLKLADLLDAINGLV 780
            |..|:|:|..|:.::|:|.::...:.:.|.||:.|||:||..||:|:.|||.||.:|.:||...:
Human  1254 TQDEIERTKQFSKDVVDLLRHQPHFRMPFNKFIPSYHHHFGRQCKLAYYGFTKLLELFEAIPDTL 1318

  Fly   781 EMKLTSDEDKKIVLSPQVARRVFAEQCENLIRNATGNSSHCMKLEQVLVLHKKKYGYQIQPKTLG 845
            :: |...|:|.:.|:.....:..|.|...|:|:...|   |:.:..:|..:.|.:||..:.:...
Human  1319 QV-LECGEEKILTLTEVERFKALAAQFVKLLRSQKDN---CLMMTDLLTEYAKTFGYTFRLQDYD 1379

  Fly   846 VMDMATAVELLPYV-------------------------------------------ELKKKEQA 867
            |..::...:.|.:|                                           |||:..::
Human  1380 VSSISALTQKLCHVVKVADIESGRQIQLINRKSLRSLTAQLLVLLMSWEGTTHLSVEELKRHYES 1444

  Fly   868 IWLICHN---NDHEFRFL----CYRVCKYVMERDPSASVWTNVRGE--VKLTKSQQFVKPIE--- 920
                .||   |..|:.|:    ..:...|::|      |:||.:.|  ||||....|.|.:.
Human  1445 ----THNTPLNPCEYGFMTLTELLKSLPYLVE------VFTNDKMEECVKLTSLYLFAKNVRSLL 1499

  Fly   921 -----KSILVRDFNAKYKDHLSES-------------ALLAMRQAIEVYDDGGIQCIRLTRFMKF 967
                 :.|.:.:|:..|..::.|:             .|.|:.|.:.:...|..:.:.|...||.
Human  1500 HTYHYQQIFLHEFSMAYTKYVGETLQPKTYGHSSVEELLGAIPQVVWIKGHGHKRIVVLKNDMKS 1564

  Fly   968 IIAIV---------------RMLEQRPSMYLYEIKNGLNCGLSTTFEFGFPNLYSVVAAHKDLFS 1017
            .::.:               |:||...|....|:|.|.:
Human  1565 RLSSLSLSPANHENQPSEGERILEVPESHTASELKLGAD-------------------------- 1603

  Fly  1018 INNGPTQERSEV-------SINMNCE-----LRQSSLSKDQCVLESQKLTNSKHRAQRSFHSHI- 1069
             .:||:....|:       .:::.|.     |....|..|..:|:|..|...:.|.|......|
Human  1604 -GSGPSHTEQELLRLTDDSPVDLLCAPVPSCLPSPQLRPDPVILQSADLIQFEERPQEPSEIMIL 1667

  Fly  1070 GEHNGLPISQPPLKRSATINNCST 1093
            .:...:.|..|...::.|.::.|:
Human  1668 NQEEKMEIPIPGKSKTLTSDSSSS 1691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marf1	NP_001246133.1	RRM_SF	253..337	CDD:302621	24/94 (26%)
		LabA_like_C	341..393	CDD:301363	16/51 (31%)
		LabA_like_C	458..519	CDD:301363	22/63 (35%)
		LabA_like_C	560..631	CDD:301363	41/70 (59%)
		LabA_like_C	636..710	CDD:301363	22/73 (30%)
		LabA_like_C	723..794	CDD:301363	26/70 (37%)
		LOTUS	805..872	CDD:193585	15/109 (14%)
MARF1	XP_005255761.1	limkain_b1_N_like	352..494	CDD:199896
		RRM1_LKAP	510..582	CDD:240701
		RRM	<777..>873	CDD:223796	28/112 (25%)
		RRM2_LKAP	788..876	CDD:240702	24/94 (26%)
		LOTUS_1_Limkain_b1	877..938	CDD:193591	17/61 (28%)
		LOTUS_2_Limkain_b1	1005..1075	CDD:193592	22/70 (31%)
		LOTUS_3_Limkain_b1	1101..1172	CDD:193593	41/70 (59%)
		LOTUS_4_Limkain_b1	1177..1248	CDD:193594	22/73 (30%)
		LOTUS_5_Limkain_b1	1261..1331	CDD:193595	26/70 (37%)
		LOTUS_6_Limkain_b1	1337..1407	CDD:193596	13/72 (18%)
		LOTUS_7_Limkain_b1	1413..1485	CDD:193597	15/81 (19%)
		LOTUS_8_Limkain_b1	1488..1563	CDD:193598	11/74 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158798
Domainoid	1	1.000	116	1.000	Domainoid score	I5996
eggNOG	1	0.900	-	-		E1_2CNB8
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006455
OrthoInspector	1	1.000	-	-		oto88336
orthoMCL	1	0.900	-	-		OOG6_107017
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5867
SonicParanoid	1	1.000	-	-		X4707
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.630