DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marf1 and marf1

DIOPT Version :9

Sequence 1:	NP_001246133.1	Gene:	Marf1 / 49895	FlyBaseID:	FBgn0039972	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_012825959.2	Gene:	marf1 / 733745	XenbaseID:	XB-GENE-990483	Length:	1682	Species:	Xenopus tropicalis

Alignment Length:	991	Identity:	269/991 - (27%)
Similarity:	456/991 - (46%)	Gaps:	178/991 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 CSRPTTTAVTIQRSTGEDGGDKEGHTFAKITEMSDAVTLQITNLDYSLDESHIRSFLLN------ 279
            ||.|..|     ..||  ..|.....||      :...:||.||||.:....::..|.:
Frog   757 CSSPIAT-----NQTG--AADNSVDPFA------NGADIQIGNLDYRMSRKELQQTLHDIFSRHG 808

  Fly   280 -----QLKPITPVVSLVFEGSSYAKVTVPDLYFAKQVVSNLHRKKIGHKRMLVSYTRDSSLTEVN 339
                 :|.|.|       :....|.|.:.:|..|...|::|||.|||.||:.||....::...::
Frog   809 KIKNVELSPHT-------DYQLKATVQMENLQEAICAVNSLHRYKIGSKRIQVSLATGATNKSLS 866

  Fly   340 TLRCQVAGLLKDVPFNTLPMYKFRELFQSRFKTSISVLDLYKMQDICTINSDNNEEKFISLNPEL 404
            .|......:|:|.|...||::||.|:::.:|...:.|.|||::.|..||. |....:.:.|.|.:
Frog   867 LLSFGTVSILQDAPACCLPLFKFTEIYEKKFGHKLIVSDLYRLTDTVTIR-DQGNGRLVCLLPSV 930

  Fly   405 V--------------NTLDISPLM-EGLQHSVPYCSIHFKKEQHKGWAEQEIEP----LPNVFMS 450
            .              ::.:.||:: |.|::..|.|..|....:..|   .:.:|    :|.|.:|
Frog   931 QARQSPMGSSQSHDGSSANCSPVVFEELEYHEPICRRHCSNRKFSG---HDFDPDSYIIPFVIIS 992

  Fly   451 ISEIQKLIYPLLKVHTGDIPVATLLHCVKEELNV--SIMANENGVNLEHLICCVQGIQVRANNFG 513
            :......::.||:.|.|.:|:.:...|...|.:.  .:...:.||.|||||.|:.|:.:.....|
Frog   993 LKTFAPQVHSLLQTHEGTVPLLSFPDCYAAEFSALKEVQEGQGGVPLEHLITCIPGVNIAFAQNG 1057

  Fly   514 IKILGWLEINKEMQSGTFNASSNTCSLTASDRTNCGSYFKNSVADP-LFQISREVIELLKMSPKS 577
            ||::.|:. ||...     .:|:...|.:          |:.|.:| |.|.|||||:|||..|..
Frog  1058 IKVVKWIH-NKPPP-----PNSDPWLLRS----------KSPVGNPQLIQFSREVIDLLKNQPSC 1106

  Fly   578 TMKFNRFIPAYHNHFGKQCRVADYGYTKLIELFEALSNVVQIMGDGENRQITLSHRIQIRRFTSD 642
            .|...:|||.||:||.|||||:||||:||:||.||:.:|:||:|.|..|.:||:||.|::|||.|
Frog  1107 IMPVTKFIPTYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGMGSKRLLTLTHRAQVKRFTQD 1171

  Fly   643 LLRVLRANGNNSVLLSQLPLVFTQTQNKTFDITDYGVCDLIDILDGLVSSNIVTLGAAQNGKDIL 707
            ||::|::..:..|::.:....:....::.:::|:||||||:||:..:..:.|..  :.|:|:.:
Frog  1172 LLKLLKSQASKQVIVREFSQAYHWCFSRDWNVTEYGVCDLVDIVSEIPDTTICV--SQQDGESV- 1233

  Fly   708 ISMPKRKQTNSELEKTCVFAGEMVELFQNALQYTILFQKFVRSYHYHFAYQCRLSDYGFLKLADL 772
            ||:|||::|..|:|:|..|:.|:|:|.::...:.:.|.||:.|||:||..||:|:.|||.||.||
Frog  1234 ISIPKRERTPEEVERTKQFSKEVVDLLRHQPHFRMPFNKFIPSYHHHFGRQCKLTYYGFTKLLDL 1298

  Fly   773 LDAINGLVEMKLTSDEDKKIVLSPQVARRVFAEQCENLIRNATGNSSHCMKLEQVLVLHKKKYGY 837
            .:||..:::: |...|:|.:.|:.....:..|.|...|:|:...:|   :.:..:|..:.|.:||
Frog  1299 FEAIPDVLQV-LECGEEKILALTEMERIKALASQLVKLLRSQKDSS---INMPDLLTEYSKTFGY 1359

  Fly   838 QIQPKTLGVMDMATAVELLPYV------ELKKKEQAIWLICHNNDHEFRFLCYRVCKYVMERDPS 896
            .::.....|..:...::.|.:|      :|.|:.|.|      |....|.|..::...:|..|.|
Frog  1360 SLRLHDYDVSSVPALMQKLCHVVKIMDTDLGKQIQLI------NRKSLRSLTAQLLILLMSWDES 1418

  Fly   897 AS--------VWTNVRGEVKLTKSQQFVKPIEKSILVRDFNAKYKDHLSESALLAMRQAIEVYD- 952
            :|        |:.:|.| :.|       .|.|...:          .|:| .|.::...:||:.
Frog  1419 SSLTVEQLCQVYQSVHG-IPL-------NPCEYGFV----------SLAE-LLKSLPYLVEVHTN 1464

  Fly   953 ---DGGIQCIRLTRFMKFIIAIVRMLEQRPSMYLYEIKNGLNCGLSTTF---EFGFPNLYSVVAA 1011
               :..:|...|..|.|.:.:::.....: .::|:|..|..:..:....   ::|:.:|..::.|
Frog  1465 DLCEDSVQLTSLYVFAKNVRSLLHTYHYQ-QIFLHEFPNAYSKYVGEVLQPKQYGYSSLEEILGA 1528

  Fly  1012 -----------HKDLFSINNGPTQERSEVSINMNCELRQSSLSKD-------QCVLESQ-----K 1053
                       ||.:..:.|.     .:|...|:.||...:...|       .|:...|     .
Frog  1529 IPQVVWIKGHGHKRIVVLKND-----MKVCHQMDKELLCLTSPMDLLCGPVPSCLPSPQLHPDPV 1588

  Fly  1054 LTNSKHRAQRSFHSHIG--------EHNGLPISQPPLKRSATINNCSTFQTYHADTDIFNVPA-- 1108
            :|......|...|.|..        ::|.|.....|         |: |.| .||.|.|:.|:
Frog  1589 VTQPADLIQFEEHFHFSDLVYPEETQYNPLCNGTQP---------CN-FPT-SADLDTFSEPSTQ 1642

  Fly  1109 NCLP--PRTNLSLPNS 1122
            |..|  .::...||.|
Frog  1643 NICPQESKSTKELPES 1658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marf1	NP_001246133.1	RRM_SF	253..337	CDD:302621	25/94 (27%)
		LabA_like_C	341..393	CDD:301363	18/51 (35%)
		LabA_like_C	458..519	CDD:301363	19/62 (31%)
		LabA_like_C	560..631	CDD:301363	41/70 (59%)
		LabA_like_C	636..710	CDD:301363	21/73 (29%)
		LabA_like_C	723..794	CDD:301363	28/70 (40%)
		LOTUS	805..872	CDD:193585	15/72 (21%)
marf1	XP_012825959.2	PIN_limkain_b1_N_like	340..462	CDD:350234
		Limkain-b1	498..583	CDD:402966
		RRM	<502..682	CDD:223796
		RRM2_LKAP	776..864	CDD:409701	27/100 (27%)
		LOTUS_1_Limkain_b1	865..926	CDD:193591	18/61 (30%)
		LOTUS_2_Limkain_b1	993..1063	CDD:193592	19/69 (28%)
		LOTUS_3_Limkain_b1	1089..1160	CDD:193593	41/70 (59%)
		LOTUS_4_Limkain_b1	1165..1236	CDD:193594	21/73 (29%)
		LOTUS_5_Limkain_b1	1249..1319	CDD:193595	28/70 (40%)
		LOTUS_6_Limkain_b1	1325..1395	CDD:193596	14/72 (19%)
		LOTUS_7_Limkain_b1	1401..1473	CDD:193597	17/90 (19%)
		LOTUS_8_Limkain_b1	1476..1551	CDD:193598	12/80 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8048
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006455
OrthoInspector	1	1.000	-	-		otm47452
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5867
SonicParanoid	1	1.000	-	-		X4707
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030