DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marf1 and Marf1

DIOPT Version :9

Sequence 1:	NP_001246133.1	Gene:	Marf1 / 49895	FlyBaseID:	FBgn0039972	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_596912.1	Gene:	Marf1 / 170946	RGDID:	619770	Length:	1735	Species:	Rattus norvegicus

Alignment Length:	1227	Identity:	308/1227 - (25%)
Similarity:	528/1227 - (43%)	Gaps:	298/1227 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 VPYQQLSTLSPTTALYSNFNNSLEAGTAERLRLN-KTGSQVHSLYVGDGQ---VQNASEPLSFPS 100
            :|.:.|...|.:....:||.     |..|..|:. |:|:::.....|.|.   :.|:....|.|:
  Rat   626 MPGKGLQANSGSATKNTNFK-----GLQELCRMEPKSGNRIRDHQQGHGSLATLPNSGPTASVPT 685

  Fly   101 HLNLYQYVRTPANFTINSRNRYIPYYNNRSYSASTT------------GFPIASTPLISSHAHIQ 153
            ..|      |....|::..::.....:::|.::|..            .:|.|.:.||:|
  Rat   686 LKN------TGVRETLHRSSQKKENLSSQSIASSPAQKKKREGTVFQISYPSAFSQLIAS----- 739

  Fly   154 DQQGAASYQTIVPLYQTASHCAQQHTTLASVAPIVDNSFVESTTCPMAGITSHNIKMKMIPPNVL 218
                    :.:.||:.:.|...:      |::|.:.|     |..|:|        ..:..|:..
  Rat   740 --------RQVSPLFSSQSWSPR------SMSPNLLN-----TASPLA--------FNIANPSSA 777

  Fly   219 LPCSRPTTTAVTIQRSTGEDGGDKEGHTFAKITEMSDAVTLQITNLDYSLDESHIRSFLLN---- 279
            ..||.|                            .::.|.:|::|:||.|....::..|..
  Rat   778 ADCSDP----------------------------FANGVDIQVSNVDYRLSRKELQQLLQEAFSK 814

  Fly   280 -------QLKPITPVVSLVFEGSSYAKVTVPDLYFAKQVVSNLHRKKIGHKRMLVSYTRDSSLTE 337
                   :|.|.|       :....|.|.:.:|:.|...|::|||.|||.|::|||.:..::...
  Rat   815 HGQVKSVELSPHT-------DYQLKAIVQMRNLHDAICAVNSLHRYKIGSKKILVSLSTGAANKS 872

  Fly   338 VNTLRCQVAGLLKDVPFNTLPMYKFRELFQSRFKTSISVLDLYKMQDICTINSDNNEEKFISLNP 402
            ::.|..:...:|:|.|...||::||.::::.::...::|.||||:.|:..|....| .:.:.|.|
  Rat   873 LSLLSTETMSILQDAPACCLPLFKFIDIYEKKYGHKLNVSDLYKLTDMIAIREQGN-GRLVCLLP 936

  Fly   403 ELVNTLDISPLMEGLQH--SVPYCS-IHFKK--------EQH---KGWAEQEIEP----LPNVFM 449
            .  |....|||.....|  |...|| :.|::        :||   |.::|...:|    :|.|.:
  Rat   937 S--NQARQSPLGSSQSHDGSSTNCSPVLFEELEYHESVCKQHCSNKDFSELVFDPDSYKVPFVVL 999

  Fly   450 SISEIQKLIYPLLKVHTGDIPVATLLHCVKEE---LNVSIMANENGVNLEHLICCVQGIQVRANN 511
            |:......::.||:.|.|.:|:.:...|...|   |.:: ...:.||.|||.|.|:.|:.:....
  Rat  1000 SLKVFAPQVHSLLQTHEGTVPLLSFPDCYAAEFGDLEIT-QDRDKGVPLEHFITCIPGVNIATAQ 1063

  Fly   512 FGIKILGWLEINKEMQSGTFNASSNTCSLTASDRTNCGSYFKNSVADP-LFQISREVIELLKMSP 575
            .|:|::.|:. ||.....|             |.....|  |:.|.:| |.|.|||||:|||..|
  Rat  1064 NGVKVVKWIH-NKPPPPNT-------------DPWLLRS--KSPVRNPQLIQFSREVIDLLKNQP 1112

  Fly   576 KSTMKFNRFIPAYHNHFGKQCRVADYGYTKLIELFEALSNVVQIMGDGENRQITLSHRIQIRRFT 640
            ...:..:.|||.||:||||||||:||||:|||||.||:.:|:||:|.|..|.:||:||.|::|||
  Rat  1113 SCILPISNFIPLYHHHFGKQCRVSDYGYSKLIELLEAVPHVLQILGMGSKRLLTLTHRAQVKRFT 1177

  Fly   641 SDLLRVLRANGNNSVLLSQLPLVFTQTQNKTFDITDYGVCDLIDILDGLVSSNIVTLGAAQNGKD 705
            .|||::.::..:..|::|.....:....:|.:|:|:|||||||||:..:..:   |:..:|...|
  Rat  1178 QDLLKLFKSQASKQVIVSDFSQAYHWCFSKDWDVTEYGVCDLIDIISEIPDT---TICLSQQDDD 1239

  Fly   706 ILISMPKRKQTNSELEKTCVFAGEMVELFQNALQYTILFQKFVRSYHYHFAYQCRLSDYGFLKLA 770
            ::|.:.||::|..|:|:|..|:.::|:|.::...:.:.|.||:.|||:||..||:|:.|||.||.
  Rat  1240 MVICIRKRERTQDEIERTKQFSKDVVDLLRHQPHFRMPFNKFIPSYHHHFGRQCKLAYYGFTKLL 1304

  Fly   771 DLLDAINGLVEMKLTSDEDKKIVLSPQVARRVFAEQCENLIRNATGNSSHCMKLEQVLVLHKKKY 835
            :||:||..:::: |...|:|.:.|:.....:..|.|...|:|:..||   |:.:..:...:.|.:
  Rat  1305 ELLEAIPEILQV-LECGEEKILTLTEVERFKALAAQFVKLLRSQKGN---CLMMTDLFTEYAKTF 1365

  Fly   836 GY--------------------------------QIQ--------PKTLGVMDMATAVE---LLP 857
            ||                                |||        |.|:.::.:..:.|   .||
  Rat  1366 GYTFRLQDYDVSSVSALTQKLCHVVKVADMESGKQIQLITRKSLRPLTVQLLVVLMSWEGDAYLP 1430

  Fly   858 YVELKKKEQAIWLICHN---NDHEFRFLCYRVCKYVMERDPS-ASVWTNVRGE--VKLTKSQQFV 916
            ..|||:..:.    .|:   |..|:.|:   ....:::..|| ..|:.|.:.|  ||||....|.
  Rat  1431 VDELKRHYET----THSTPLNPCEYGFM---TLTELLKSLPSLVEVFMNDKAEECVKLTSLYLFA 1488

  Fly   917 KPIE--------KSILVRDFNAKYKDHLSES-------------ALLAMRQAIEVYDDGGIQCIR 960
            |.:.        :.|.:.:|...|..::.|:             .|.|:.|.:.:...|..:.:.
  Rat  1489 KNVRSLLHTYHYQQIFLHEFAMAYTKYVGETLQPKTYGYSSVEELLGAIPQVVWIKGHGHKRIVV 1553

  Fly   961 LTRFMK-----FIIAIVRMLEQRP--SMYLYEIKNGLNCGLSTTFEFGFPNLYSVVAAHKDLFSI 1018
            |...||     |.::.|.. |.:|  |..:.|:..              |:|.|.:       .:
  Rat  1554 LKNDMKNRLSSFDLSPVNH-EDQPAVSRQILEVPE--------------PHLASEL-------HL 1596

  Fly  1019 NNGPTQERSEV-------SINMNCE-----LRQSSLSKDQCVLESQKLTNSKHRAQRSFHSHIG- 1070
            ..||:|...|:       .:::.|.     |....|..|..:|:...|...:...|..    :|
  Rat  1597 RTGPSQMEQELLQLANSSPVDLLCAPVPSCLPSPQLRPDPVILQPTDLIQFEEHPQEP----LGV 1657

  Fly  1071 ------EHNGLPISQPPLKRSATINNCSTFQTYHADTDIFNVPANC-LPPRTNLSLP 1120
                  |...:||   |:|:.....|.|.           :.||:. .||:.:...|
  Rat  1658 LFLNQEEKTEIPI---PVKKGNLSCNSSP-----------SSPASASAPPKPSSEAP 1700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marf1	NP_001246133.1	RRM_SF	253..337	CDD:302621	25/94 (27%)
		LabA_like_C	341..393	CDD:301363	15/51 (29%)
		LabA_like_C	458..519	CDD:301363	18/63 (29%)
		LabA_like_C	560..631	CDD:301363	42/70 (60%)
		LabA_like_C	636..710	CDD:301363	24/73 (33%)
		LabA_like_C	723..794	CDD:301363	27/70 (39%)
		LOTUS	805..872	CDD:193585	20/109 (18%)
Marf1	NP_596912.1	limkain_b1_N_like	350..492	CDD:199896
		RRM1_LKAP	507..579	CDD:240701
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	617..639		3/12 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..721		12/67 (18%)
		RRM2_LKAP	784..872	CDD:240702	15/98 (15%)
		LabA_like_C	873..934	CDD:301363	16/60 (27%)
		LOTUS_2_Limkain_b1	1001..1071	CDD:193592	21/90 (23%)
		LOTUS_3_Limkain_b1	1097..1168	CDD:193593	22/71 (31%)
		LOTUS_4_Limkain_b1	1173..1244	CDD:193594	39/70 (56%)
		LOTUS_5_Limkain_b1	1257..1327	CDD:193595	24/69 (35%)
		LabA_like_C	1333..1403	CDD:301363	26/69 (38%)
		LOTUS_7_Limkain_b1	1409..1481	CDD:193597	18/117 (15%)
		LOTUS_8_Limkain_b1	1484..1559	CDD:193598	21/102 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1671..1718		7/37 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352790
Domainoid	1	1.000	86	1.000	Domainoid score	I7910
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006455
OrthoInspector	1	1.000	-	-		otm44405
orthoMCL	1	0.900	-	-		OOG6_107017
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4707
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.740