DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fis1 and FIS1

DIOPT Version :9

Sequence 1:	NP_001137607.1	Gene:	Fis1 / 49892	FlyBaseID:	FBgn0039969	Length:	154	Species:	Drosophila melanogaster
Sequence 2:	NP_057152.2	Gene:	FIS1 / 51024	HGNCID:	21689	Length:	152	Species:	Homo sapiens

Alignment Length:	155	Identity:	75/155 - (48%)
Similarity:	104/155 - (67%)	Gaps:	10/155 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDLLNEVVPQEDLERFEKKYHHELELDGEVTTDTKFEYAFCLVRSRYTNDVRKGIMILEELART 65
            ||.:|||:|..|||.:||||:..| :..|.|:..|:||||:|||||:|.:|:||||::||||.
Human     1 MEAVLNELVSVEDLLKFEKKFQSE-KAAGSVSKSTQFEYAWCLVRSKYNDDIRKGIVLLEELL-- 62

  Fly    66 HPDG----RRDYIYYLAFGNARIKEYTSGLKYCRAFLDIE-SNDQVRSLEEYIKKEIDKEVAKGM 125
             |.|    :|||::|||.||.|:|||...|||.|..|..| .|:|.:.||..|.|.:.|:...||
Human    63 -PKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGM 126

  Fly   126 VVAGGAALVLGGILGL-GIAMARNK 149
            .:.||.||.:.|:.|| |:|::::|
Human   127 AIVGGMALGVAGLAGLIGLAVSKSK 151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fis1	NP_001137607.1	Fis1	9..120	CDD:276936	57/115 (50%)
		TPR repeat	33..65	CDD:276936	20/31 (65%)
		TPR repeat	69..100	CDD:276936	18/34 (53%)
FIS1	NP_057152.2	Fis1	9..123	CDD:276936	58/117 (50%)
FIS1	NP_057152.2	TPR	71..104		18/32 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159295
Domainoid	1	1.000	52	1.000	Domainoid score	I11562
eggNOG	1	0.900	-	-		E1_KOG3364
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41099
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4576
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58557
OrthoDB	1	1.010	-	-		D1595957at2759
OrthoFinder	1	1.000	-	-		FOG0003777
OrthoInspector	1	1.000	-	-		oto88907
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R448
SonicParanoid	1	1.000	-	-		X6325
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.900