DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo7b and Mhc

DIOPT Version :9

Sequence 1:NP_001178870.1 Gene:Myo7b / 498834 RGDID:1561153 Length:2152 Species:Rattus norvegicus
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:2035 Identity:501/2035 - (24%)
Similarity:827/2035 - (40%) Gaps:443/2035 - (21%)


- Green bases have known domain annotations that are detailed below.


  Rat    11 WLDPPSSNKTGVAIGGIVKETKLGKTLIEDDEGKEHWISAEDLSTLRPMHPNSAQGVDDMIRLGD 75
            |:   ...|.|..:|.| |.||.....:....|:...|.:|   .:..::|...:.::||..:..
  Fly    39 WI---PDEKEGYLLGEI-KATKGDIVSVGLQGGEVRDIKSE---KVEKVNPPKFEKIEDMADMTV 96

  Rat    76 LNEAGVVHNLLIRYQQHKIYTYTGSILVAVNPFQMLPLYTLEQVQIYYSRHMGELPPHVFAIANS 140
            ||...|:|||..||....||||:|...||:||::..|:||....::|..:...|:|||:|||::.
  Fly    97 LNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDG 161

  Rat   141 CYFNMKKNKRDQCCIISGESGAGKTETTKLILQFLATVSGQHSW---------IEQQVLEANPIL 196
            .|.:|..|..:|..:|:|||||||||.||.::.:.|||......         :|.||::.||:|
  Fly   162 AYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVL 226

  Rat   197 EAFGNAKTIRNDNSSRFGKYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAAEERNYHIFYCMLMG 261
            ||||||||:||||||||||:|.|||..:|.:.||.||.:||||:||..|.:.||:|||||.::.|
  Fly   227 EAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSG 291

  Rat   262 -------MSLEEKNMLGLGMPSEYHYLTMGNCTSYEGLSDAKDYAHVRSAMKILQFSDSENWDIS 319
                   :.|...|:.      :||.::.|..| ...:.||::::....|..||.|:..|..|:.
  Fly   292 SVPGVKDICLLTDNIY------DYHIVSQGKVT-VASIDDAEEFSLTDQAFDILGFTKQEKEDVY 349

  Rat   320 KLLAAILHLGNVGFMAAVFENLDSSDVMETPAFPFAMKLLEVQHQALRDCLIKHTIPILGEFVSR 384
            ::.||::|:|.:.|.....|.....|..|...  ...||.......|...|:|..|.:..|||::
  Fly   350 RITAAVMHMGGMKFKQRGREEQAEQDGEEEGG--RVSKLFGCDTAELYKNLLKPRIKVGNEFVTQ 412

  Rat   385 PLNIAQAADRRDAFVKGIYGHLFLWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSF 449
            ..|:.|..:...|..||::..||.|:|||.|..:.|.|.:     :..||:|||.|||.|:.|.|
  Fly   413 GRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKR-----QHFIGVLDIAGFEIFEYNGF 472

  Rat   450 EQLCINFANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLAL-----KPMSIISL 509
            |||||||.||.|||||..|:|.:|||||..|.|.|.:|.:.     :|:||.     |||.|:|:
  Fly   473 EQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFG-----MDLLACIDLIEKPMGILSI 532

  Rat   510 LDEESRFPQGTDVTMLQKLNSIHANNKS-FLRPK-------SIHDTRFGIAHFAGDVYYQAEGFL 566
            |:|||.||:.||.|..:||.:.|....: |.:||       :.|   |.|||:||.|.|...|:|
  Fly   533 LEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAH---FAIAHYAGCVSYNITGWL 594

  Rat   567 EKNRDVLSTDILILIHSSKNKFLKEIF------NLDLPQTKLGHGTICQVKTKTGGQIFKPSDST 625
            |||:|.|:..::.....|:||.|.|||      :....|.|.|.|       |.||..       
  Fly   595 EKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRG-------KKGGGF------- 645

  Rat   626 KRSVTLSSQFKQSLEQLMKILTNCQPYFVRCIKPNEYKKPLLFDRELCIQQLRYSGMMETVHIRK 690
               .|:||.:|:.|..||..|.:.||:|||||.|||.|:|.:.|..|.:.||..:|::|.:.|.:
  Fly   646 ---ATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICR 707

  Rat   691 SGFPIRYTFDEFSQRFRVLLPS-PERVQFQNKHRQMTSRIADLCLGTDKEWKMGKTKIFLKDHQD 754
            .|||.|..:.:|..|::::.|. .:.|:...|..::..:..||   .:.::::|.||:|.:....
  Fly   708 KGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEIIIKFIDL---PEDQYRLGNTKVFFRAGVL 769

  Rat   755 TMLEIQRSQALDGAAIRIQRVLRGHKYRKEFLRQKRAAVTLQAVWRGHNQRKNFKL--------- 810
            ..:|..|.:.|......:|...||:..||.|.:.:...|.|:.|.|  |.||..:|         
  Fly   770 GQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQR--NLRKYLQLRTWPWYKLW 832

  Rat   811 ----ILMGFERLQ-AIARSHLLMRQFQTM-------RQKIVQLQARC--------------RGYL 849
                .|:...|:: .|||.....::.:.:       |:::..|.|:.              :|.|
  Fly   833 QKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGAL 897

  Rat   850 VRQQVQAKRRAVVIIQAH-------------ARGMVARKSYWQQKSSGPPVILAKEPKGQGVAL- 900
               |...:|.|.:..|.:             .:...||...:|||......|...:...:.:.| 
  Fly   898 ---QDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELN 959

  Rat   901 -----------DRKRKSIYDTVTDTAMV-------EKVFGFLPAMIGGQEGPAPTRFEDL-EVKT 946
                       |.:.:::.|.:.....:       :|:.|......|.:...|..:...| :||.
  Fly   960 VQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKA 1024

  Rat   947 ---QKLHEVDLDTVPM-------TEMPGEDVDGLAEYTFPKFAVTYFQKSASHTHIQKPLRYPLL 1001
               |.|.|:: |::..       .|.....|:|..:.|....|.....|......||:       
  Fly  1025 KLEQTLDELE-DSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQR------- 1081

  Rat  1002 YHENDTDHSAALA----VWIIILRFMGDLPEPQAYGRSSLTGSSVMRQIHDRLDKDSVTQGPQHN 1062
               .|.:.|:..|    ..:::|:....:.|.||.          :.::.:.::.:...:.....
  Fly  1082 ---KDKELSSITAKLEDEQVVVLKHQRQIKELQAR----------IEELEEEVEAERQARAKAEK 1133

  Rat  1063 RSTQVASQ-QNIGEEVFKFDGPIS---------------------------DRPMSNLEKVHFIV 1099
            :...:|.: :.:||.:.:..|..|                           :..::||.|.|   
  Fly  1134 QRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKH--- 1195

  Rat  1100 GYAIMRPGLRDEIYCQICKQLSENYKTSSRARGWILLSLCLGCFPPSERFMKY-LLNFISQG--- 1160
                      ::...::.:|:.:..|..::|.              .|:...| .||.:..|   
  Fly  1196 ----------NDAVAEMAEQVDQLNKLKAKAE--------------KEKNEYYGQLNDLRAGVDH 1236

  Rat  1161 ---PASYGPFCAERLQRTFANGVRAEPPTWLELQAVKSKKHIPIQVILATGRSLT--------IS 1214
               ..:.....|::||.|              |..|:||       :..|.|:|.        :|
  Fly  1237 ITNEKAAQEKIAKQLQHT--------------LNEVQSK-------LDETNRTLNDFDASKKKLS 1280

  Rat  1215 VDSASTSREICQQIAQKQGLRDKLGFSLQVAVYD-----------------KFWSLGNSCDHVMD 1262
            ::::...|::.:..:|...| .|:..||...:.|                 ||.:|.:..|::.:
  Fly  1281 IENSDLLRQLEEAESQVSQL-SKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLRE 1344

  Rat  1263 AVAQCEQLAWERGESQRQAPWRIYFRKEFFTPWHDSREDPVSTELIYHQVLRGVWSGEYNFE--- 1324
               |.|:.|..:.:.|||.                |:.:..:.          ||..:|..:   
  Fly  1345 ---QVEEEAEGKADLQRQL----------------SKANAEAQ----------VWRSKYESDGVA 1380

  Rat  1325 KEEDLVELLARHCYVQLGATVKSNAVQELLPSCVPSKLYRTKSPEKWASLVIAAHAKAPYTQSKA 1389
            :.|:|.|...:   :|.........::.|...|:  .|.:||  ::.::.|.....:.....:.|
  Fly  1381 RSEELEEAKRK---LQARLAEAEETIESLNQKCI--GLEKTK--QRLSTEVEDLQLEVDRANAIA 1438

  Rat  1390 TPLEVKEQTVEAARLLWPLLFSRLFEVTTLSGP--RLPKTQLILAINWKGMYFLDQKERTLL--- 1449
            ...|.|::..:.....|.|....|......|..  |...|:|   ...||.|...|::...:   
  Fly  1439 NAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTEL---FRLKGAYEEGQEQLEAVRRE 1500

  Rat  1450 GLSFAEVMGLIANRDAPGGKSL--------LLSTLHEEYEFASPSSVAIAEMVALFLAGLKERSV 1506
            ..:.|:.:..:.::...||:::        .|....:|.:.|...:.|..|.        :|..|
  Fly  1501 NKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQ--------EENKV 1557

  Rat  1507 FAMALQDRKATDDVTLLPFKKGDLLILTKKQGLLASENWVLG-QNDRTGKTGLVPTACLYTIPSV 1570
            ....|:..:...::.....:|.:....|:|....|.::.... :.:..||...:         .:
  Fly  1558 LRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEAL---------RM 1613

  Rat  1571 TKPSAQLLNLLAMSPEKRKLAAQEVQASEPPLEEQLTELPYTLEEFSYQYFRAPEKETISRAAMP 1635
            .|.....:|.|.::.:....|..|.|.:....::||.::...|||.......|.|:..||     
  Fly  1614 KKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGIS----- 1673

  Rat  1636 MARSRGHLWAYSPEPLRQPLLKSVHDKAKLRDSACQIFLAILKYTGDYPSRQSWHSL-------- 1692
                         |.....|...:.:...|.:.|            |...||:...|        
  Fly  1674 -------------ERRANALQNELEESRTLLEQA------------DRGRRQAEQELADAHEQLN 1713

  Rat  1693 ELTDQMFSLALKEPALQDELYCQILKQLTH-------NSIRFSEERAWQLLWLCTGLFPPGKALL 1750
            |::.|..|::..:..|:.||      |..|       |..:.|||:|.:.:.....|....:|..
  Fly  1714 EVSAQNASISAAKRKLESEL------QTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQ 1772

  Rat  1751 PHAQKFIDSRKK-----KPLALDCSRRLHRILRVGPRKQPPHHVEVKAAEQNVSKLHHEV----Y 1806
            .|||.....||.     |.|.:.........|:.|.:       .::..||.|.:|.:|:    .
  Fly  1773 DHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKK-------AIQKLEQRVRELENELDGEQR 1830

  Rat  1807 LPNDTNKTLEVSSSSRVRDL 1826
            ...|..|.|. .|..||::|
  Fly  1831 RHADAQKNLR-KSERRVKEL 1849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo7bNP_001178870.1 MYSc 60..761 CDD:214580 275/736 (37%)
MYSc_Myo7 79..750 CDD:276832 269/706 (38%)
IQ 787..809 CDD:197470 7/21 (33%)
MyTH4 991..1194 CDD:214535 31/241 (13%)
B41 1201..1414 CDD:214604 40/240 (17%)
FERM_B-lobe 1304..1405 CDD:271216 16/103 (16%)
FERM_C1_MyoVII 1408..1504 CDD:270019 18/108 (17%)
SH3 1505..1565 CDD:302595 8/60 (13%)
MyTH4 1646..1793 CDD:214535 32/166 (19%)
B41 1802..2014 CDD:214604 8/29 (28%)
FERM_M 1912..2014 CDD:278785
FERM_C2_MyoVII 2010..2105 CDD:270020
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 9/37 (24%)
MYSc 81..777 CDD:214580 275/737 (37%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 269/706 (38%)
Myosin_tail_1 842..1897 CDD:279860 198/1181 (17%)
V_Alix_like 1557..1877 CDD:187408 67/346 (19%)
ATP-synt_B <1671..1771 CDD:304375 24/135 (18%)
TMPIT 1739..>1825 CDD:285135 20/92 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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