Protein Alignment OPRM1 and AstA-R2

DIOPT Version :10

• Sequence 1: NP_001138751.1
• Gene: OPRM1 / 4988
• HGNCID: 8156
• Length: 493
• Species: Homo sapiens
• Sequence 2: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Alignment Length: 332
• Identity: 110/332 - (33%)
• Similarity: 168/332 - (50%)
• Gaps: 56/332 - (16%)

Human   170 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTI 233
            :.::.:.|.|||.||:.|:|....|::.||:.|.|||.||.: ....:||.:.:|::..||:|..
  Fly    45 FGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRF 109

Human   234 LCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVM 298
            .|:.|..:.....|.||:||..||:||::||.||:::...||.....|..|..||:...:.:||.
  Fly   110 WCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVPVA 174

Human   299 FM--------ATTKYRQGSIDCTLT---FSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMIL 352
            |.        |......|.  ||.|   |..|..|     ::..||.::::|::||:..|..||:
  Fly   175 FTHDVVVDYDAKKNITYGM--CTFTTNDFLGPRTY-----QVTFFISSYLLPLMIISGLYMRMIM 232

Human   353 RL----KSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIP--------- 404
            ||    ..|||   |||..|..:|:||:|:|||..|...|.|:.:.:::|:|..|.
  Fly   233 RLWRQGTGVRM---SKESQRGRKRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETNTLTKLVI 294

Human   405 ETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREF--CIPTSSNIEQQNSTRIRQNTRD 467
            :.|.||        |.|::||:||:|||||.|||::.|.:.  |           |:|.:..|.|
  Fly   295 QVTAQT--------LAYSSSCINPLLYAFLSENFRKAFYKAVNC-----------SSRYQNYTSD 340

Human   468 HPSTANT 474
            .|....|
  Fly   341 LPPPRKT 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPRM1	NP_001138751.1	7tmA_Mu_opioid_R	164..442	CDD:320218	102/296 (34%)
		TM helix 1	165..191	CDD:320218	8/20 (40%)
		TM helix 2	198..224	CDD:320218	10/26 (38%)
		TM helix 3	235..265	CDD:320218	12/29 (41%)
		TM helix 4	277..299	CDD:320218	6/21 (29%)
		TM helix 5	324..353	CDD:320218	8/28 (29%)
		TM helix 6	368..398	CDD:320218	11/29 (38%)
		TM helix 7	410..435	CDD:320218	11/24 (46%)
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	102/296 (34%)
		TM helix 1	40..66	CDD:320224	8/20 (40%)
		TM helix 2	73..99	CDD:320224	10/25 (40%)
		TM helix 3	111..141	CDD:320224	12/29 (41%)
		TM helix 4	153..173	CDD:320224	4/19 (21%)
		TM helix 5	204..233	CDD:320224	10/33 (30%)
		TM helix 6	249..279	CDD:320224	11/29 (38%)
		TM helix 7	292..317	CDD:320224	13/32 (41%)