Protein Alignment OPRM1 and SIFaR

DIOPT Version :10

• Sequence 1: NP_001138751.1
• Gene: OPRM1 / 4988
• HGNCID: 8156
• Length: 493
• Species: Homo sapiens
• Sequence 2: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Alignment Length: 486
• Identity: 126/486 - (25%)
• Similarity: 226/486 - (46%)
• Gaps: 92/486 - (18%)

Human    71 LGTRKVSVLLATSHSGARPAVSTMDSSAAPTNASNCTDALAYSSCSPAPSPGS--WVNLSHLDGN 133
            |||     :|.|:.:...||.|::.::.|.|..::...:||..|.:.|.:..|  :.||.:|
  Fly   106 LGT-----VLTTATATVAPAASSLLATLAATTTASARGSLAGKSLAIADATSSTYYSNLLNL--- 162

Human   134 LSDPCGPNRTDL---------------------GGRDSLCPPTGSPSMITAITIMALYSIVCVVG 177
                 .|..|.|                     |..|....|....|:..::.....|.:|.:||
  Fly   163 -----SPATTSLISAAAATKSYNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVG 222

Human   178 LFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSVNYLMGTWPFGTILCKIVISI 241
            |.||..|:.|::|..:|:|.||.:|.|||:||.|. ...||...:..:...|..|.::||.|..|
  Fly   223 LIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYI 287

Human   242 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLP-VMFMATTKY 305
            ...::..|:::|..:|:||:||:..|:|.:   |.|.|:|:.:..|:::....:| ::|......
  Fly   288 QGVSVAASVYSLIAVSLDRFIAIWWPLKQM---TKRRARIMIIGIWVIALVTTIPWLLFFDLVPA 349

Human   306 RQGSIDCTLT-FSHPTW----YWE-----NLLKICVFIFA-FIMPVLIITVCYGLMILRLKSVRM 359
            .:...|..:: :|.|.:    .|.     ||..:...:.| :::|:.:||:||.|:.::: |.|.
  Fly   350 EEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLIWIKV-STRS 413

Human   360 LSGSKEKDRNLRR--------ITRMVLVVVAVFIVCWTPIH-IYVIIKALVTIPETTFQTVSWHF 415
            :.| :.||..:.|        :.:|::.||.:|::.|.|:: |:..||....|.:..|:.:....
  Fly   414 IPG-ESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKKVM 477

Human   416 CIA--LGYTNSCLNPVLYAFLDENFKRCF------REFC---------IPTSSNIEQQNSTRIRQ 463
            .:|  ||.:|||:||:||: :::.::|.|      |..|         ...||....:.|:...|
  Fly   478 PVAQWLGSSNSCINPILYS-VNKKYRRGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQ 541

Human   464 N-TRDHPSTA----------NTVDRTNHQLE 483
            | :|..||:.          |::.|.|..|:
  Fly   542 NSSRKSPSSKGNAVSYIYEHNSLRRHNMMLK 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPRM1	NP_001138751.1	7tmA_Mu_opioid_R	164..442	CDD:320218	86/301 (29%)
		TM helix 1	165..191	CDD:320218	9/25 (36%)
		TM helix 2	198..224	CDD:320218	11/26 (42%)
		TM helix 3	235..265	CDD:320218	11/29 (38%)
		TM helix 4	277..299	CDD:320218	5/22 (23%)
		TM helix 5	324..353	CDD:320218	9/34 (26%)
		TM helix 6	368..398	CDD:320218	8/38 (21%)
		TM helix 7	410..435	CDD:320218	10/26 (38%)
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	86/301 (29%)
		TM helix 1	210..236	CDD:320124	9/25 (36%)
		TM helix 2	243..269	CDD:320124	11/25 (44%)
		TM helix 3	281..311	CDD:320124	11/29 (38%)
		TM helix 4	322..340	CDD:320124	3/17 (18%)
		TM helix 5	379..404	CDD:320124	8/24 (33%)
		TM helix 6	429..459	CDD:320124	7/29 (24%)
		TM helix 7	474..498	CDD:320124	10/24 (42%)