Protein Alignment OPRM1 and AstC-R1

DIOPT Version :10

• Sequence 1: NP_001138751.1
• Gene: OPRM1 / 4988
• HGNCID: 8156
• Length: 493
• Species: Homo sapiens
• Sequence 2: NP_649040.2
• Gene: AstC-R1 / 40020
• FlyBaseID: FBgn0036790
• Length: 483
• Species: Drosophila melanogaster
• Alignment Length: 397
• Identity: 132/397 - (33%)
• Similarity: 195/397 - (49%)
• Gaps: 68/397 - (17%)

Human    93 TMDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGS 157
            |.||.|..||..|..::| |::           .|:|...:.|....|..: |.|.|.   ||..
  Fly    18 TADSEANATNWYNTNESL-YTT-----------ELNHRWISGSSTIQPEES-LYGTDL---PTYQ 66

Human   158 PSMITA-----ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLP 217
            ..:.|.     :..:.||..||::|||||.||:||::|::||:|.|||||.|||:||......:|
  Fly    67 HCIATRNSFADLFTVVLYGFVCIIGLFGNTLVIYVVLRFSKMQTVTNIYILNLAVADECFLIGIP 131

Human   218 FQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKII 282
            |......:.:|.||..:||..:.......|||...|..||.|||||||||:.:..:||...||::
  Fly   132 FLLYTMRICSWRFGEFMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTLHIAKVV 196

Human   283 NVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWEN---LLKICVFIFAFIMPVLIIT 344
            :...|..|:.:.|||:..|:|..::..|:.:.....|..|.::   ...:..|...|..|:..|.
  Fly   197 SAIAWSTSAVLMLPVILYASTVEQEDGINYSCNIMWPDAYKKHSGTTFILYTFFLGFATPLCFIL 261

Human   345 VCYGLMILRLKSVRMLSG--SKEKDRNLRRITRMVLVVVAVFIVCWTP--------IH------- 392
            ..|.|:|.:|:||....|  ||||.|..|::||:||.|::|:|:||.|        ||
  Fly   262 SFYYLVIRKLRSVGPKPGTKSKEKRRAHRKVTRLVLTVISVYILCWLPHWISQVALIHSNPAQRD 326

Human   393 -------IYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC-FREFCIPT 449
                   |::::.|||                   |:||.:||:|||||.|||::. |:.|....
  Fly   327 LSRLEILIFLLLGALV-------------------YSNSAVNPILYAFLSENFRKSFFKAFTCMN 372

Human   450 SSNIEQQ 456
            ..:|..|
  Fly   373 KQDINAQ 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPRM1	NP_001138751.1	7tmA_Mu_opioid_R	164..442	CDD:320218	109/305 (36%)
		TM helix 1	165..191	CDD:320218	13/25 (52%)
		TM helix 2	198..224	CDD:320218	12/25 (48%)
		TM helix 3	235..265	CDD:320218	13/29 (45%)
		TM helix 4	277..299	CDD:320218	7/21 (33%)
		TM helix 5	324..353	CDD:320218	7/31 (23%)
		TM helix 6	368..398	CDD:320218	15/51 (29%)
		TM helix 7	410..435	CDD:320218	9/24 (38%)
AstC-R1	NP_649040.2	7tmA_AstC_insect	78..364	CDD:320222	109/304 (36%)
		TM helix 1	79..105	CDD:320222	13/25 (52%)
		TM helix 2	112..138	CDD:320222	12/25 (48%)
		TM helix 3	149..179	CDD:320222	13/29 (45%)
		TM helix 4	191..213	CDD:320222	7/21 (33%)
		TM helix 5	241..270	CDD:320222	7/28 (25%)
		TM helix 6	287..317	CDD:320222	12/29 (41%)
		TM helix 7	332..357	CDD:320222	13/43 (30%)