Protein Alignment OPRM1 and CCKLR-17D3

DIOPT Version :10

• Sequence 1: NP_001138751.1
• Gene: OPRM1 / 4988
• HGNCID: 8156
• Length: 493
• Species: Homo sapiens
• Sequence 2: NP_001097023.1
• Gene: CCKLR-17D3 / 32864
• FlyBaseID: FBgn0030954
• Length: 584
• Species: Drosophila melanogaster
• Alignment Length: 481
• Identity: 109/481 - (22%)
• Similarity: 180/481 - (37%)
• Gaps: 161/481 - (33%)

Human    81 ATSHSGARPAVSTMDSSAAPTNASNCTDALAYS---SCSPAPSPGSWVNLSHLDGNLSDPCGPNR 142
            |||..|.......||     |..|:....||:|   |.||:||              |.|...:.
  Fly    60 ATSSYGDDDRDGYMD-----TEPSDLVTELAFSLGTSSSPSPS--------------STPASSSS 105

Human   143 TDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLAL 207
            |.          ||.|     :.::..||::.:..:.||.||:..:|:..:|:|.||:::.|||:
  Fly   106 TS----------TGMP-----VWLIPSYSMILLFAVLGNLLVISTLVQNRRMRTITNVFLLNLAI 155

Human   208 AD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKAL 271
            :| .|....:|...|..|:..:.||..|||:.......::..|.:||..:|.:||.|:|||:::.
  Fly   156 SDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSWTLVAISCERYYAICHPLRSR 220

Human   272 DFRTPRNA-KIINVCNWILSSAIGLPV----MFMATTKYRQGSIDCTLTFSHPTWYWENLLKICV 331
            .::|..:| |||... |:.......|:    ..:.|:  |.|...|...:  |...:|....|.:
  Fly   221 SWQTISHAYKIIGFI-WLGGILCMTPIAVFSQLIPTS--RPGYCKCREFW--PDQGYELFYNILL 280

Human   332 FIFAFIMPVLIITVCYGLMILRLKSVRML------------------------------------ 360
            .....::|:|::.|.| ::|.|...|.|.
  Fly   281 DFLLLVLPLLVLCVAY-ILITRTLYVGMAKDSGRILQQSLPVSATTAGGSAPNPGTSSSSNCILV 344

Human   361 --------------SGSKE---------------------------------------------K 366
                          :|:.|                                             .
  Fly   345 LTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVITTTTTTTVTLAKTSSPSIRVH 409

Human   367 DRNLR------------RITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSW---HFC 416
            |..||            |:.:|:.|:|..|.:||||  :|||...::.|....::.|.:   .|.
  Fly   410 DAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTP--LYVINTMVMLIGPVVYEYVDYTAISFL 472

Human   417 IALGYTNSCLNPVLYAFLDENFKRCF 442
            ..|.|::||.||:.|.|::.:|:|.|
  Fly   473 QLLAYSSSCCNPITYCFMNASFRRAF 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPRM1	NP_001138751.1	7tmA_Mu_opioid_R	164..442	CDD:320218	86/393 (22%)
		TM helix 1	165..191	CDD:320218	7/25 (28%)
		TM helix 2	198..224	CDD:320218	9/26 (35%)
		TM helix 3	235..265	CDD:320218	9/29 (31%)
		TM helix 4	277..299	CDD:320218	6/26 (23%)
		TM helix 5	324..353	CDD:320218	7/28 (25%)
		TM helix 6	368..398	CDD:320218	14/41 (34%)
		TM helix 7	410..435	CDD:320218	10/27 (37%)
CCKLR-17D3	NP_001097023.1	7tm_GPCRs	112..498	CDD:475119	86/393 (22%)
		TM helix 1	114..138	CDD:320334	6/23 (26%)
		TM helix 2	147..169	CDD:320334	7/21 (33%)
		TM helix 3	185..207	CDD:320334	4/21 (19%)
		TM helix 4	230..246	CDD:320334	4/16 (25%)
		TM helix 5	274..297	CDD:320334	5/23 (22%)
		TM helix 6	429..451	CDD:320334	11/23 (48%)
		TM helix 7	466..491	CDD:320334	9/24 (38%)