DRSC/TRiP Functional Genomics Resources

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Protein Alignment OPRM1 and CCKLR-17D1

DIOPT Version :10

Sequence 1:NP_001138751.1 Gene:OPRM1 / 4988 HGNCID:8156 Length:493 Species:Homo sapiens
Sequence 2:NP_001097021.1 Gene:CCKLR-17D1 / 32860 FlyBaseID:FBgn0259231 Length:673 Species:Drosophila melanogaster


Alignment Length:555 Identity:110/555 - (19%)
Similarity:193/555 - (34%) Gaps:201/555 - (36%)


- Green bases have known domain annotations that are detailed below.


Human    88 RPAVSTMDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLS--------HLDGNLSDPCG--PNR 142
            |.|:.....:|...||||...|:. ...:...:||..:|.|        .||.||.....  |:.
  Fly    87 RQALPLAKEAAIHLNASNEISAVG-DGVTITGTPGDLLNYSGLELDLGLDLDLNLDMDLATTPSS 150

Human   143 TDLGGRDSLCPPTGSPSMI-----TAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYI 202
            :.|....::..| |:.|::     ..|.::..||.:.:..:.||.||:..:|:..:|:|.||:::
  Fly   151 STLAPAVTVRTP-GNRSVVRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFL 214

Human   203 FNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCH 266
            .|||::| .|....:|...|..|:..:.||.:|||::......::..|.:||..:|.:||.|:||
  Fly   215 LNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICH 279

Human   267 PVKALDFRTPRNAKIINVCNWILSSAIGLPV----MFMATTKYRQGSIDCTLTFSHPTWYWENLL 327
            |:::..::|..:|..|....|:.|.....|:    ..|.|:  |.|...|...:...:..:|...
  Fly   280 PLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLMPTS--RPGLRKCREQWPADSLNYERAY 342

Human   328 KICVFIFAFIMPVLIITVCYGLMILR--------------------------------------- 353
            .:.:.:...::|:|.::..| |.|.|                                       
  Fly   343 NLFLDLALLVLPLLALSFTY-LFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRAN 406

Human   354 ------------------------------------------------------------LKSVR 358
                                                                        :||:|
  Fly   407 GSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLR 471

Human   359 ---------MLSG-------------------------------SKEKD---------------- 367
                     .|||                               |:.|.                
  Fly   472 HQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRS 536

Human   368 ------RNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSW---HFCIALGYTN 423
                  .:.:|:.:|:.|:|..|.:||||  :|||....:.:..|.::.|.:   .|...|.|::
  Fly   537 NETKSLESKKRVVKMLFVLVLEFFICWTP--LYVINTMTMLLGPTVYEYVGYTSISFLQLLAYSS 599

Human   424 SCLNPVLYAFLDENFKRCF----------REFCIP 448
            ||.||:.|.|::.:|:|.|          ...|.|
  Fly   600 SCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAP 634

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OPRM1NP_001138751.1 7tmA_Mu_opioid_R 164..442 CDD:320218 86/446 (19%)
TM helix 1 165..191 CDD:320218 7/25 (28%)
TM helix 2 198..224 CDD:320218 9/26 (35%)
TM helix 3 235..265 CDD:320218 9/29 (31%)
TM helix 4 277..299 CDD:320218 5/25 (20%)
TM helix 5 324..353 CDD:320218 6/28 (21%)
TM helix 6 368..398 CDD:320218 12/29 (41%)
TM helix 7 410..435 CDD:320218 10/27 (37%)
CCKLR-17D1NP_001097021.1 7tm_GPCRs 177..618 CDD:475119 85/445 (19%)
TM helix 1 178..202 CDD:410628 6/23 (26%)
TM helix 2 211..233 CDD:410628 7/21 (33%)
TM helix 3 249..271 CDD:410628 4/21 (19%)
TM helix 4 294..310 CDD:410628 3/15 (20%)
TM helix 5 340..363 CDD:410628 3/23 (13%)
TM helix 6 549..571 CDD:410628 11/23 (48%)
TM helix 7 586..611 CDD:410628 9/24 (38%)

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