Protein Alignment OPRM1 and Oprm1

DIOPT Version :10

• Sequence 1: NP_001138751.1
• Gene: OPRM1 / 4988
• HGNCID: 8156
• Length: 493
• Species: Homo sapiens
• Sequence 2: NP_001291884.1
• Gene: Oprm1 / 18390
• MGIID: 97441
• Length: 474
• Species: Mus musculus
• Alignment Length: 388
• Identity: 364/388 - (93%)
• Similarity: 373/388 - (96%)
• Gaps: 2/388 - (0%)

Human    94 MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSP 158
            |||||.|.|.|:|:|.||.:|||||  ||||:||||:|||.|||||||||.|||..||||.||||
Mouse     1 MDSSAGPGNISDCSDPLAPASCSPA--PGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSP 63

Human   159 SMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNY 223
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    64 SMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNY 128

Human   224 LMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWI 288
            ||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||:||||||
Mouse   129 LMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWI 193

Human   289 LSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILR 353
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   194 LSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILR 258

Human   354 LKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIA 418
            |||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
Mouse   259 LKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIA 323

Human   419 LGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQ 481
            |||||||||||||||||||||||||||||||||.||||||.|||||||:||||||||||||||
Mouse   324 LGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQ 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPRM1	NP_001138751.1	7tmA_Mu_opioid_R	164..442	CDD:320218	274/277 (99%)
		TM helix 1	165..191	CDD:320218	25/25 (100%)
		TM helix 2	198..224	CDD:320218	25/25 (100%)
		TM helix 3	235..265	CDD:320218	29/29 (100%)
		TM helix 4	277..299	CDD:320218	20/21 (95%)
		TM helix 5	324..353	CDD:320218	28/28 (100%)
		TM helix 6	368..398	CDD:320218	29/29 (100%)
		TM helix 7	410..435	CDD:320218	24/24 (100%)
Oprm1	NP_001291884.1	7tmA_Mu_opioid_R	69..347	CDD:320218	274/277 (99%)
		TM helix 1	70..96	CDD:320218	25/25 (100%)
		TM helix 2	103..129	CDD:320218	25/25 (100%)
		TM helix 3	140..170	CDD:320218	29/29 (100%)
		TM helix 4	182..204	CDD:320218	20/21 (95%)
		TM helix 5	229..258	CDD:320218	28/28 (100%)
		TM helix 6	273..303	CDD:320218	29/29 (100%)
		TM helix 7	315..340	CDD:320218	24/24 (100%)
		NPxxY, plays a role in stabilizing the activated conformation of the receptor. /evidence=ECO:0000269|PubMed:26245379	332..336		3/3 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..383		18/20 (90%)