Protein Alignment OPRL1 and sNPF-R

DIOPT Version :10

• Sequence 1: NP_001305782.1
• Gene: OPRL1 / 4987
• HGNCID: 8155
• Length: 399
• Species: Homo sapiens
• Sequence 2: NP_524176.1
• Gene: sNPF-R / 40195
• FlyBaseID: FBgn0036934
• Length: 600
• Species: Drosophila melanogaster
• Alignment Length: 355
• Identity: 101/355 - (28%)
• Similarity: 154/355 - (43%)
• Gaps: 72/355 - (20%)

Human    42 HGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLP 105
            |..|:.:...|    ||..|.|.|:.||.||.||:||:..|:|.|||:|.||||:|.|: :|.:|
  Fly    58 HNQFVQIFFYV----LYATVFVLGVFGNVLVCYVVLRNRAMQTVTNIFITNLALSDILLCVLAVP 118

Human   106 FQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAV 170
            |......:|.|.||.:||..|......:::.||.|||::::|||..|.:|....  ...|....:
  Fly   119 FTPLYTFMGRWAFGRSLCHLVSFAQGCSIYISTLTLTSIAIDRYFVIIYPFHPR--MKLSTCIGI 181

Human   171 NVAIWALASVVGVP--------------------------------------------------- 184
            .|:||.:|.:..||
  Fly   182 IVSIWVIALLATVPYGMYMKMTNELVNGTQTGNETLVEATLMLNGSFVAQGSGFIEAPDSTSATQ 246

Human   185 ----VAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYS-LMIRRLRG 244
                |...||...|...:....|...|.:.:..||........|::|..:||:||. :.::..:.
  Fly   247 AYMQVMTAGSTGPEMPYVRVYCEENWPSEQYRKVFGAITTTLQFVLPFFIISICYVWISVKLNQR 311

Human   245 VRLLSGSR-----EKDRN-LRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRF 303
            .|...||:     |.||: .:|..|:::.:||||...|.|:.|..:..... ..|:|....||.|
  Fly   312 ARAKPGSKSSRREEADRDRKKRTNRMLIAMVAVFGLSWLPINVVNIFDDFD-DKSNEWRFYILFF 375

Human   304 CTA--LGYVNSCLNPILYAFLDENFKACFR 331
            ..|  :...::|.||.|||:|:|||:..|:
  Fly   376 FVAHSIAMSSTCYNPFLYAWLNENFRKEFK 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPRL1	NP_001305782.1	7tmA_NOFQ_opioid_R	52..330	CDD:320220	98/342 (29%)
		TM helix 1	53..79	CDD:320220	12/25 (48%)
		TM helix 2	86..112	CDD:320220	13/26 (50%)
		TM helix 3	123..153	CDD:320220	10/29 (34%)
		TM helix 4	165..187	CDD:320220	8/76 (11%)
		TM helix 5	212..241	CDD:320220	8/29 (28%)
		TM helix 6	256..286	CDD:320220	10/30 (33%)
		TM helix 7	298..323	CDD:320220	10/26 (38%)
sNPF-R	NP_524176.1	7tmA_NPYR-like	64..404	CDD:320331	98/346 (28%)
		TM helix 1	65..91	CDD:320331	13/29 (45%)
		TM helix 2	98..123	CDD:320331	13/24 (54%)
		TM helix 3	136..166	CDD:320331	10/29 (34%)
		TM helix 4	177..198	CDD:320331	6/20 (30%)
		TM helix 5	278..307	CDD:320331	8/28 (29%)
		TM helix 6	329..359	CDD:320331	9/29 (31%)
		TM helix 7	372..397	CDD:320331	10/24 (42%)