Protein Alignment OPRL1 and Lkr

DIOPT Version :10

• Sequence 1: NP_001305782.1
• Gene: OPRL1 / 4987
• HGNCID: 8155
• Length: 399
• Species: Homo sapiens
• Sequence 2: NP_647968.3
• Gene: Lkr / 38622
• FlyBaseID: FBgn0035610
• Length: 542
• Species: Drosophila melanogaster
• Alignment Length: 337
• Identity: 103/337 - (30%)
• Similarity: 162/337 - (48%)
• Gaps: 38/337 - (11%)

Human    54 IVGLYLAVCVGGL-----LGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTDIL 112
            ||.| |::..||:     :||.||::|:....:|:|.||:||.|||.||.:: |..:|||....|
  Fly    34 IVAL-LSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQAAL 97

Human   113 LGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWAL 177
            |..|.....:|.....:...::..|.|||||:::||:.||.:|:||...:..||  .:...||.|
  Fly    98 LQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSK--FIIGGIWML 160

Human   178 ASVVGVPVAIMGSAQVED-----EEIECLVEIPTP-------QDYWGPVFAICIFLFSFIVPVLV 230
            |.:..||.||  :.:||:     .|......:..|       .|.....|...:....::||..|
  Fly   161 ALLFAVPFAI--AFRVEELTERFRENNETYNVTRPFCMNKNLSDDQLQSFRYTLVFVQYLVPFCV 223

Human   231 ISVCYSLMIRRLRGVRLLSGSRE-KD----RNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGV 290
            ||..|..|..||.|.|....::: :|    :|.:::.:::::||.:|..||.|:|::.:......
  Fly   224 ISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLIIVVIIFGLCWLPLQLYNILYVTIP 288

Human   291 QPSSETAVAILRFCTA-LGYVNSCLNPILYAFLDENFK--------ACFRKF-CCASALRRDVQV 345
            :.:....::|:.||.. |...|||.||.:|...:|.||        |||.|| ....|..|...:
  Fly   289 EINDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKRFAACFCKFKTSMDAHERTFSM 353

Human   346 SDRVRSIAKDVA 357
            ..|..||....|
  Fly   354 HTRASSIRSTYA 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPRL1	NP_001305782.1	7tmA_NOFQ_opioid_R	52..330	CDD:320220	93/307 (30%)
		TM helix 1	53..79	CDD:320220	11/29 (38%)
		TM helix 2	86..112	CDD:320220	13/26 (50%)
		TM helix 3	123..153	CDD:320220	10/29 (34%)
		TM helix 4	165..187	CDD:320220	8/21 (38%)
		TM helix 5	212..241	CDD:320220	8/28 (29%)
		TM helix 6	256..286	CDD:320220	8/29 (28%)
		TM helix 7	298..323	CDD:320220	10/25 (40%)
Lkr	NP_647968.3	7tmA_leucokinin-like	36..329	CDD:320515	90/297 (30%)
		TM helix 1	37..63	CDD:320515	9/26 (35%)
		TM helix 2	70..95	CDD:320515	13/24 (54%)
		TM helix 3	108..138	CDD:320515	10/29 (34%)
		TM helix 4	149..170	CDD:320515	8/22 (36%)
		TM helix 5	205..234	CDD:320515	8/28 (29%)
		TM helix 6	254..284	CDD:320515	8/29 (28%)
		TM helix 7	297..322	CDD:320515	10/24 (42%)