Protein Alignment OPRL1 and CCHa1-R

DIOPT Version :10

• Sequence 1: NP_001305782.1
• Gene: OPRL1 / 4987
• HGNCID: 8155
• Length: 399
• Species: Homo sapiens
• Sequence 2: NP_611241.2
• Gene: CCHa1-R / 37004
• FlyBaseID: FBgn0050106
• Length: 499
• Species: Drosophila melanogaster
• Alignment Length: 352
• Identity: 104/352 - (29%)
• Similarity: 171/352 - (48%)
• Gaps: 42/352 - (11%)

Human    45 FLPLGLK-----VTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLL-T 103
            ::|.|.:     |.|  |:..:.|.|:|||..::.|.|...:|:...|.||.:|||||.||:: |
  Fly    72 YVPYGRRPETYIVPI--LFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVIITT 134

Human   104 LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDV-----RT 163
            :|...|...:.:||:|:.||.....:...::..|.|||||:|.|||.||..|:|....     |.
  Fly   135 VPLASTVYTVEYWPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRA 199

Human   164 SSKAQAVNVAIWALASVVGVPVAIMGS--AQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIV 226
            :....|..|:||.||.:.|:| |::||  ..:...|...::..|.|:: ||..:|..:.|..|:|
  Fly   200 TRMTLATAVSIWLLAILCGLP-ALIGSNLKHLGINEKSIVICYPYPEE-WGINYAKSMVLLHFLV 262

Human   227 ----PVLVISVCYSLMIRRLR------GVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQV 281
                |::||:|.|.|:...|.      |.  :.|:..:.|..|::...||..|.:|..|:.|..|
  Fly   263 YYAIPLVVIAVFYVLIALHLMYSASVPGE--IQGAVRQVRARRKVAVTVLAFVVIFGICFLPYHV 325

Human   282 FVLAQGLGVQPSSET-------AVAILRFCTALGYVNSCLNPILYAFLDENFKACFRK--FCCAS 337
            |.|  .....|:::.       .:.|:.:|  :.:.|||.||:...|:...|:..|.:  ||..:
  Fly   326 FFL--WFYFWPTAQDDYNAFWHVLRIVAYC--MSFANSCANPVALYFVSGAFRKHFNRYLFCRGA 386

Human   338 ALRRDVQVSDRVRSIAKDVALACKTSE 364
            :.||..:.......:.:|.:|....|:
  Fly   387 SGRRKKRGQHDTFCMHRDTSLTSTASK 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPRL1	NP_001305782.1	7tmA_NOFQ_opioid_R	52..330	CDD:320220	94/302 (31%)
		TM helix 1	53..79	CDD:320220	9/25 (36%)
		TM helix 2	86..112	CDD:320220	13/26 (50%)
		TM helix 3	123..153	CDD:320220	12/29 (41%)
		TM helix 4	165..187	CDD:320220	8/21 (38%)
		TM helix 5	212..241	CDD:320220	11/32 (34%)
		TM helix 6	256..286	CDD:320220	11/29 (38%)
		TM helix 7	298..323	CDD:320220	8/24 (33%)
CCHa1-R	NP_611241.2	7tmA_Bombesin_R-like	82..377	CDD:320593	94/304 (31%)
		TM helix 1	83..109	CDD:320593	10/27 (37%)
		TM helix 2	116..142	CDD:320593	13/25 (52%)
		TM helix 3	154..184	CDD:320593	12/29 (41%)
		TM helix 4	201..221	CDD:320593	8/20 (40%)
		TM helix 5	252..277	CDD:320593	9/24 (38%)
		TM helix 6	300..330	CDD:320593	11/31 (35%)
		TM helix 7	345..370	CDD:320593	8/26 (31%)