Protein Alignment OPRL1 and CCHa2-R

DIOPT Version :10

• Sequence 1: NP_001305782.1
• Gene: OPRL1 / 4987
• HGNCID: 8155
• Length: 399
• Species: Homo sapiens
• Sequence 2: NP_001356958.1
• Gene: CCHa2-R / 35535
• FlyBaseID: FBgn0033058
• Length: 501
• Species: Drosophila melanogaster
• Alignment Length: 341
• Identity: 97/341 - (28%)
• Similarity: 158/341 - (46%)
• Gaps: 45/341 - (13%)

Human    36 LLLNASHGAFLPLGLK-------------VTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATN 87
            |.|:..|.|....|:.             ||:  ||..:.:.|:|||..::.:..||..|:...|
  Fly    43 LALDMGHNASADGGIVPYVPVLDRPETYIVTV--LYTLIFIVGVLGNGTLVIIFFRHRSMRNIPN 105

Human    88 IYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVA 151
            .||.:|||||.||:|. :|..........|||...:|:........::..|.|||||:|.:||.|
  Fly   106 TYILSLALADLLVILVCVPVATIVYTQESWPFERNMCRISEFFKDISIGVSVFTLTALSGERYCA 170

Human   152 ICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMG---SAQVEDEEIECLVEIPTPQDYWGP 213
            |.:|:|.|..:..:...|  |.||.||.::|:|..:..   |..|........:|:.:|  :..|
  Fly   171 IVNPLRKLQTKPLTVFTA--VMIWILAILLGMPSVLFSDIKSYPVFTATGNMTIEVCSP--FRDP 231

Human   214 VFAICIF----LFSFIVPVLVISVCYSLMIRRLR-GVRLLSG------SREKDRNLRRITRLVLV 267
            .:|..:.    |..:::|:.:|...|.:|.:||. ..|.:.|      ||.:.|....:.|:|:.
  Fly   232 EYAKFMVAGKALVYYLLPLSIIGALYIMMAKRLHMSARNMPGEQQSMQSRTQARARLHVARMVVA 296

Human   268 VVAVFVGCWTPVQVFVLAQGLGVQPSSE-------TAVAILRFCTALGYVNSCLNPILYAFLDEN 325
            .|.||..|:.|..||.|  .....|::|       ..:.|:.|||:  ::|||:||:....:...
  Fly   297 FVVVFFICFFPYHVFEL--WYHFYPTAEEDFDEFWNVLRIVGFCTS--FLNSCVNPVALYCVSGV 357

Human   326 FKACFRKFCCASALRR 341
            |:..|.::.|...::|
  Fly   358 FRQHFNRYLCCICVKR 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPRL1	NP_001305782.1	7tmA_NOFQ_opioid_R	52..330	CDD:320220	89/299 (30%)
		TM helix 1	53..79	CDD:320220	7/25 (28%)
		TM helix 2	86..112	CDD:320220	12/26 (46%)
		TM helix 3	123..153	CDD:320220	11/29 (38%)
		TM helix 4	165..187	CDD:320220	8/21 (38%)
		TM helix 5	212..241	CDD:320220	7/32 (22%)
		TM helix 6	256..286	CDD:320220	11/29 (38%)
		TM helix 7	298..323	CDD:320220	9/24 (38%)
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	89/301 (30%)
		TM helix 1	71..97	CDD:320593	8/27 (30%)
		TM helix 2	104..130	CDD:320593	12/25 (48%)
		TM helix 3	142..172	CDD:320593	11/29 (38%)
		TM helix 4	182..202	CDD:320593	7/21 (33%)
		TM helix 5	234..259	CDD:320593	5/24 (21%)
		TM helix 6	285..315	CDD:320593	11/31 (35%)
		TM helix 7	330..355	CDD:320593	9/26 (35%)