Protein Alignment OPRL1 and CCKLR-17D1

DIOPT Version :10

• Sequence 1: NP_001305782.1
• Gene: OPRL1 / 4987
• HGNCID: 8155
• Length: 399
• Species: Homo sapiens
• Sequence 2: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Alignment Length: 548
• Identity: 106/548 - (19%)
• Similarity: 184/548 - (33%)
• Gaps: 194/548 - (35%)

Human    11 EVIYGSHLQGNLSL---LSPNHSLLPPHLLLNASH-------GAFLPLGLKVTIVGLYLAVCVGG 65
            |:..|..|..||.:   .:|:.|.|.|.:.:....       .|.:|    :.:|..|.|:.:..
  Fly   129 ELDLGLDLDLNLDMDLATTPSSSTLAPAVTVRTPGNRSVVRVSADVP----IWVVPCYSAILLCA 189

Human    66 LLGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAI 129
            ::||.||:..::::.:|:|.||:::.|||::|.|: :..:|......||..:.||..|||.:...
  Fly   190 VVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFA 254

Human   130 DYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVE 194
            ...::..|::||.|:|.:||.|||||:|:...:|.:.|..:...||..:.|...|:|........
  Fly   255 QAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLMPT 319

Human   195 DEE--IECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRL-------RGV----- 245
            ...  .:|..:.|.....:...:.:.:.|...::|:|.:|..|..:.|.|       |.:
  Fly   320 SRPGLRKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSS 384

Human   246 ------------------------------------------------------------RLLSG 250
                                                                        ||:||
  Fly   385 GPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISG 449

Human   251 ----------------------------------------------------------------- 250
                                                                             
  Fly   450 GGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDN 514

Human   251 -SREKD----------------------RNLRRITRLVLVVVAVFVGCWTPVQVF-VLAQGLGVQ 291
             ||.|.                      .:.:|:.:::.|:|..|..||||:.|. .:...||..
  Fly   515 ESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPT 579

Human   292 PSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACF----------RKFCCASALRRDVQVS 346
            .........:.|...|.|.:||.|||.|.|::.:|:..|          .:.|......|....:
  Fly   580 VYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPCCFWRRRSKN 644

Human   347 DRVRSIA-KDVALA--CKTSETV---PR 368
            :...|:| ..:|||  ..:|.|:   ||
  Fly   645 ETNLSVAGNSIALANSVMSSHTILESPR 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPRL1	NP_001305782.1	7tmA_NOFQ_opioid_R	52..330	CDD:320220	83/441 (19%)
		TM helix 1	53..79	CDD:320220	7/25 (28%)
		TM helix 2	86..112	CDD:320220	8/26 (31%)
		TM helix 3	123..153	CDD:320220	10/29 (34%)
		TM helix 4	165..187	CDD:320220	5/21 (24%)
		TM helix 5	212..241	CDD:320220	5/28 (18%)
		TM helix 6	256..286	CDD:320220	9/30 (30%)
		TM helix 7	298..323	CDD:320220	10/24 (42%)
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	83/440 (19%)
		TM helix 1	178..202	CDD:410628	7/23 (30%)
		TM helix 2	211..233	CDD:410628	7/21 (33%)
		TM helix 3	249..271	CDD:410628	5/21 (24%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	4/22 (18%)
		TM helix 6	549..571	CDD:410628	8/21 (38%)
		TM helix 7	586..611	CDD:410628	10/24 (42%)