Protein Alignment OPRK1 and npr-24

DIOPT Version :10

• Sequence 1: NP_001305426.1
• Gene: OPRK1 / 4986
• HGNCID: 8154
• Length: 409
• Species: Homo sapiens
• Sequence 2: NP_510833.3
• Gene: npr-24 / 187897
• WormBaseID: WBGene00020086
• Length: 373
• Species: Caenorhabditis elegans
• Alignment Length: 357
• Identity: 92/357 - (25%)
• Similarity: 167/357 - (46%)
• Gaps: 49/357 - (13%)

Human    54 ISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTV 118
            |.| |..:....:.:..::|:..|..|:..|:.:..|:|.:||||||||:||.|....:|.  ::
 Worm    14 IDP-IKTVAHLTWCLTALIGIPANLFVLAAIVYFRDMRTISNIYIFNLAVADLLFLCGIPV--SL 75

Human   119 YLMNS---WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI 180
            :..:|   |.:|.::||:.||.:..:.|.|...:.::|.|||:|||.|:::..|||...|..:::
 Worm    76 FAQSSHDGWIWGPIMCKLYISGNAVSQFASAVFIAILSFDRYLAVCRPIQSKSFRTTQAAFALSV 140

Human   181 CIWLL----------------SSSVGIS-----AIVLGGTKVRED-VDVIECSLQFPDDDYSWWD 223
            ..|::                |||.|.:     .:.:|...|.|. .::.|..|...:.:.....
 Worm   141 AAWIMVILEMTPLFLFVKLIKSSSAGEARGGSCMLFVGNVTVLESATEMNETLLNEIEQNMLASR 205

Human   224 LFMKICVFIFAFVIPVLIIIVCYTLMILRL--KSVRLLSGSREKDRNLRRITRLVLVVVAVFVVC 286
            .|.....|..:::||::.:...|..:||::  :..::.:......:...::|.:.|.:|..:..|
 Worm   206 RFFISYTFALSYLIPLVAVWYFYFKIILKMCQRKRQMQTKRTATKKRTTKVTIMGLAIVISYTHC 270

Human   287 WTPIHIFILVEALGSTSHSTAALSSY------YFCIALGYTNSSLNPILYAFLDENFKRCFR--- 342
            |.|   |.:|:  .|...:....|.|      :|..||.|.||:.||.||.||.::|::..:
 Worm   271 WLP---FWIVQ--WSIEANLFEKSKYLLFCCTHFAFALQYINSAANPFLYVFLSDSFQKNIQKLL 330

Human   343 -----DFCFPLKMRMERQSTSRVRNTVQDPAY 369
                 |....||...:.|.||::.|...:|.|
 Worm   331 RTAKPDKQIMLKNSTDPQDTSKMLNVTNNPLY 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPRK1	NP_001305426.1	7tmA_Kappa_opioid_R	60..341	CDD:320219	80/313 (26%)
		TM helix 1	61..87	CDD:320219	4/25 (16%)
		TM helix 2	94..120	CDD:320219	12/25 (48%)
		TM helix 3	131..161	CDD:320219	11/29 (38%)
		TM helix 4	173..195	CDD:320219	6/42 (14%)
		TM helix 5	223..252	CDD:320219	6/28 (21%)
		TM helix 6	267..297	CDD:320219	7/29 (24%)
		TM helix 7	309..334	CDD:320219	13/30 (43%)
npr-24	NP_510833.3	7tm_GPCRs	25..326	CDD:475119	80/307 (26%)
		TM helix 1	25..45	CDD:410628	4/19 (21%)
		TM helix 2	54..76	CDD:410628	12/23 (52%)
		TM helix 3	92..114	CDD:410628	5/21 (24%)
		TM helix 4	137..153	CDD:410628	1/15 (7%)
		TM helix 5	206..229	CDD:410628	4/22 (18%)
		TM helix 6	257..279	CDD:410628	8/26 (31%)
		TM helix 7	293..319	CDD:410628	11/25 (44%)