Protein Alignment OPRK1 and Oprk1

DIOPT Version :10

• Sequence 1: NP_001305426.1
• Gene: OPRK1 / 4986
• HGNCID: 8154
• Length: 409
• Species: Homo sapiens
• Sequence 2: NP_001305664.1
• Gene: Oprk1 / 18387
• MGIID: 97439
• Length: 409
• Species: Mus musculus
• Alignment Length: 409
• Identity: 383/409 - (93%)
• Similarity: 397/409 - (97%)
• Gaps: 0/409 - (0%)

Human     1 MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAV 65
            |:||||||||:|||||:|||||.||||:|||.|||.|||||.||||.|||.||||||||||||||
Mouse     1 MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPVIITAV 65

Human    66 YSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVL 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||
Mouse    66 YSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVL 130

Human   131 CKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIV 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||
Mouse   131 CKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIV 195

Human   196 LGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLS 260
            ||||||||||||||||||||||:|||||||||||||:||||||||||||||||||||||||||||
Mouse   196 LGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLS 260

Human   261 GSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSL 325
            |||||||||||||:|||||||||::||||||||||||||||||||||||||||||||||||||||
Mouse   261 GSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSL 325

Human   326 NPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPVXLVVEMSSYS 390
            ||:|||||||||||||||||||:|||||||||:||||||||||.:||:.|||||| ||||||||.
Mouse   326 NPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPVXLVVEMSSYC 390

Human   391 SSGREEFNDLGLTQITTAV 409
            |.|||||||||||||||||
Mouse   391 SPGREEFNDLGLTQITTAV 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPRK1	NP_001305426.1	7tmA_Kappa_opioid_R	60..341	CDD:320219	272/280 (97%)
		TM helix 1	61..87	CDD:320219	25/25 (100%)
		TM helix 2	94..120	CDD:320219	24/25 (96%)
		TM helix 3	131..161	CDD:320219	29/29 (100%)
		TM helix 4	173..195	CDD:320219	20/21 (95%)
		TM helix 5	223..252	CDD:320219	27/28 (96%)
		TM helix 6	267..297	CDD:320219	26/29 (90%)
		TM helix 7	309..334	CDD:320219	23/24 (96%)
Oprk1	NP_001305664.1	7tmA_Kappa_opioid_R	60..341	CDD:320219	272/280 (97%)
		TM helix 1	61..87	CDD:320219	25/25 (100%)
		TM helix 2	94..120	CDD:320219	24/25 (96%)
		TM helix 3	131..161	CDD:320219	29/29 (100%)
		TM helix 4	173..195	CDD:320219	20/21 (95%)
		TM helix 5	223..252	CDD:320219	27/28 (96%)
		TM helix 6	267..297	CDD:320219	26/29 (90%)
		TM helix 7	309..334	CDD:320219	23/24 (96%)