Protein Alignment SCAPER and ssp3

DIOPT Version :10

• Sequence 1: XP_047288576.1
• Gene: SCAPER / 49855
• HGNCID: 13081
• Length: 1431
• Species: Homo sapiens
• Sequence 2: NP_609917.2
• Gene: ssp3 / 35149
• FlyBaseID: FBgn0032723
• Length: 1732
• Species: Drosophila melanogaster
• Alignment Length: 1805
• Identity: 413/1805 - (22%)
• Similarity: 660/1805 - (36%)
• Gaps: 659/1805 - (36%)

Human    66 DGKPK-CQTGGKSKRTIQGTHKTTKQSTAVDC--------KITSSTTGDKHFDKSPTKTRHPRKI 121
            :|.|| ||:         .|....|.|.:|.|        ::.|::||            ..:|.
  Fly    77 NGTPKNCQS---------PTSPRLKSSASVGCGGGSSGGPRVRSASTG------------RDKKS 120

Human   122 DLRARYWAFLFDNLRRAVDEIYVTCESDQSVVECKEVLMMLDNYVRDFKALIDWIQLQEKLEKTD 186
            :|:|||||.||.||:||::|||.|.|..:::..|:|.:::|:|||||||||.:|.::....|...
  Fly   121 ELQARYWALLFGNLQRAINEIYQTVECYENISSCQETILVLENYVRDFKALCEWFKVSWDYESRP 185

Human   187 AQSRPTSLAWEVKKMSPGRHV------------------IP-------SPSTD------------ 214
            .|.||.||||||:|.:|...|                  .|       ||..|
  Fly   186 LQQRPQSLAWEVRKSNPTPRVRTRSLCSPNNSGKSSPALFPGTQSGETSPFCDNGQISPRKLLRA 250

Human   215 ---------RINV---------------------------------------------------- 218
                     |:||
  Fly   251 YDQVPKGAMRLNVRELFAASKRATQGSSQSDNMEGPLDLSGDKSNFVLRSTQYAQTDLEDPHLTL 315

Human   219 ---------------------------------TSNARRSLNF---------------------- 228
                                             ..:|..|||.
  Fly   316 ADVREKMRMEAEEREAQNRIENEALEEVTIPIDNEDATESLNKQEPSSLELPIHNVADLSKEPEL 380

Human   229 ----------------------------------------------------------------- 228
                                                                             
  Fly   381 MEAASEATALEMTVASLESMENALLNQQANKEPTPPSTVIKPLAEILKKPQPLNPLSGNNVQNSP 445

Human   229 ------------------GG----------------------------STGTVPAPRLAPTGVSW 247
                              ||                            .|.|.| |.:..||.|.
  Fly   446 LKYSSVLNRPSKKMIPPPGGVAAQKTISTKPGLVKPNLTTTVNGLRSTKTATAP-PAIKTTGRSG 509

Human   248 -------ADKVKAHHTGSTASSEI----------------TPAQSCPPMT-----------VQKA 278
                   :.|.:.:...:..:|.:                :.|::.|..|           .:.:
  Fly   510 LQRHPRPSSKTECYGPPNNVASRLSARSRTMLEINGRNTNSSARTLPKKTNPGSILSTATRTKMS 574

Human   279 SRKNERKDA----------------------------------------EGWETVQRGRPIRSRS 303
            ||.:.|:|.                                        :||.||:.    |.|:
  Fly   575 SRLSSREDITSSTSTLKASNEQLSNSRNTLKAENQHSEPKQIQPPTDADDGWLTVKN----RRRT 635

Human   304 T-------------AVMPKVSLATEATRSKDDSDKENVCLLPDESIQKGQFVGDGTSNTI----- 350
            :             |.:|.::|..|..:.::..:|           |||:..|.....||
  Fly   636 SMHWANRFNQPTGYASLPTLALLNEQQKEQEHKEK-----------QKGEDDGKVIVKTISAKTK 689

Human   351 ----------------------------ESHP--KDSLHSCDHP-LAEKTQFT----VSTLDDVK 380
                                        .|.|  |.:.:....| ..||:..|    :::..:.:
  Fly   690 APIEVAKAKAKTSIVITRPEIKNAKAKVNSFPVQKSNTNQVKKPEKQEKSDTTAPAAIASSSNTR 754

Human   381 NSG------------------------SIRDNYVR--------------------TSEISAVHID 401
            ||.                        |:...|:|                    :|..||..:.
  Fly   755 NSSHSICVGRNSIIKRQKSDLTGLKMTSLHKEYMRSEKNALRKLQQKEQGNQQHNSSSSSAETVV 819

Human   402 TEC------VSVMLQAGTPPLQVNEEKFPAEKARIENEMDPSDISNVSAANLSMAEVLAKKEELA 460
            ..|      :.:.:|......:...|.:.:    |.:...||.....:|:.||..:  ..:|:..
  Fly   820 ESCNEDHSKIDIKIQTNCEFSKTIGELYES----IAHCKLPSGSLKTNASTLSACD--ENEEQNT 878

Human   461 DRLEKANEEAIASAIAEEEQLTREIEAEENNDINIETDND-SDFSA------------SMGSG-- 510
            |..|:...|.|...:  :|.|.|:|...|..:|:::|:.| :|...            .||||
  Fly   879 DDNEEERNERILGEV--QESLERQIRELEQTEIDVDTETDETDCEVQLEEQDDGVDGLEMGSGDD 941

Human   511 SVSFCGMSMDWNDVLADYEAR-ESWRQNTSWGD------IVEEEPARPPGHGIHMHEKLSSPSRK 568
            |..|..||.|.|   |..|.| ::...:.||.:      .::...||.||....:|:|||||||:
  Fly   942 SAVFVTMSDDEN---ASLELRYQALLSDMSWNERAEALATLQAYVARHPGRAQELHQKLSSPSRR 1003

Human   569 RTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAE 633
            |::.|:.||::.||.:|||.|..|::||..|||:|..|.:||:..|.::::.:|:.|:.:|..|.
  Fly  1004 RSLQETLKKYQAKQARAQQKRNLLQQEKAAKLQQLFSRVEDVKAAKNQIIEDKRQKMQGRLQRAA 1068

Human   634 FKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQ 698
            ..||..|:.|::||.:||.|:.||.||..:||||||.|:|...||.|.||.:|::|||:|.|||.
  Fly  1069 ENREQYLKQIIEKAHDEEKKLKEINFIKNIEAQNKRLDLLESSKETEGRLQDLEQERQKRVEEKL 1133

Human   699 ARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALT 763
            |::.||:.|::|||.||..::|::...|.|:|.||.:.:::|||.|:..|||:||||||||.||.
  Fly  1134 AKEAAVERRRQALEKERLLKLEKMNETRLEKEQRIGKMQEQKEKQRQALAREKARDREERLLALQ 1198

Human   764 AAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELS-SGRHANTDYAPKLTPYERKKQCSL 827
            ..||:..||||:||..|..||.|||.|.||..:::|.||: ..|.|:
  Fly  1199 VQQQQTTEELQRKILQKQMESARRHEENIEHIRQRALELTIPTRQAD------------------ 1245

Human   828 CNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKD 892
                           :||..|....:..:......::|:.:             .|::.:|...:
  Fly  1246 ---------------EGRGDQDVSEDILNGNATSTTNEDCD-------------LSSSLSEVGGN 1282

Human   893 GEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQVQVQDSGSWAN 957
            ....:..|||.||:|.|||..|.||...:|.      .|..|:.......||..| |:..|:
  Fly  1283 NAHTRSYKKKMKKLKQRMNQCAAEYLESLEA------LPAHARRDSTVPKLLNLV-VKGGGA--- 1337

Human   958 NKVSALDRTLGEITRILEKENVADQIAFQAAGGLTAL-EHILQAVVPATNVNTVLRIPPKSLCNA 1021
               ..|||.||.:.|::.|....|.:||....||..| .|::     :..::....|..||:..|
  Fly  1338 ---QGLDRNLGNLLRVIPKAQTLDFLAFLCMDGLGILANHVI-----SKGMDENSEISRKSVYLA 1394

Human  1022 INVYNLTCNNCSENCSDVLFSNKITFLMDLLIHQLTVYVPDENNTILGRNTNKQVFEGLTTGLLK 1086
            ..:|...|:.|.:.....|..|.||.|.|.:  ..:..:|:|.        :.|....|:|.|:
  Fly  1395 AQLYRNACSVCPQIARHALLGNSITVLFDAI--NKSFQLPEEK--------SPQHPVELSTELM- 1448

Human  1087 VSAVVLGCLIANRPDGNCQPATPKIPTQEMKNKPSQGDPFNNRVQDLISYVVNMGLIDKLCACFL 1151
                 |.|..|.......:...||:|               .|:.|:|:|.|..|||:.|.....
  Fly  1449 -----LACTEALSSSYVKKNTHPKVP---------------ERLPDMINYAVITGLIEILSRRIQ 1493

Human  1152 SVQGPVDENPKMAIFLQHAAGLLHAMCTLCFAVTGRSYSIFDNNRQDPTGLTAALQATDLAGVLH 1216
            .|:..::.|..:.:.|....|.|.....:|           .....|||.|.:|.::|:|.|.:.
  Fly  1494 KVRESIESNKSVMLSLLTTLGFLSRFIDVC-----------QPGPADPTRLLSAAKSTELFGTVS 1547

Human  1217 MLY-CVLFHGTILDPSTASPKENYTQNTIQVAIQSLRFFNSFAALHLPAFQSIVGAEG-LSLAFR 1279
            ||| ||:..|..:.|.|.:           :|..:...:.|.|:|.:..||..:..|| |||...
  Fly  1548 MLYGCVMPMGECIPPRTTA-----------LAASTFHLYVSLASLDVNTFQETLTVEGPLSLKLL 1601

Human  1280 HMASSLLGHCSQV---------SCESLLHEVIVCVGYFTVNHPDNQVIVQSGRHPTVLQKLCQLP 1335
            .:.:.:| :||.|         ||..|: :::..:.:|.||:..:|.::.|.::..:.:::.:||
  Fly  1602 DVMTVIL-NCSLVNDQWTTNSESCPMLI-DLVASMAFFCVNNRRHQDLLISEQYAVIFKRMAKLP 1664

Human  1336 FQYFSDPRLIKVLFPSLIAACYNNHQNKIILEQEMSCVLLATFIQ-DLAQ 1384
            .|:  :|    |::|.|:...:||...:..|.::.....|..:.: ::||
  Fly  1665 TQF--NP----VIYPFLVTVSFNNPPAREFLSKDFDLTFLDEYSKSEMAQ 1708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCAPER	XP_047288576.1	SCAPER_N	114..211	CDD:406813	45/121 (37%)
		SMC_N	<370..742	CDD:481474	134/447 (30%)
		Smc	<568..>802	CDD:440809	109/233 (47%)
		ZnF_U1	821..853	CDD:197732	3/31 (10%)
ssp3	NP_609917.2	SCAPER_N	113..208	CDD:406813	46/106 (43%)
		Smc	878..>1192	CDD:440809	125/318 (39%)