Protein Alignment SCAPER and scpr-1

DIOPT Version :10

• Sequence 1: XP_047288576.1
• Gene: SCAPER / 49855
• HGNCID: 13081
• Length: 1431
• Species: Homo sapiens
• Sequence 2: NP_001364617.1
• Gene: scpr-1 / 189368
• WormBaseID: WBGene00012389
• Length: 1311
• Species: Caenorhabditis elegans
• Alignment Length: 1474
• Identity: 317/1474 - (21%)
• Similarity: 543/1474 - (36%)
• Gaps: 439/1474 - (29%)

Human   102 TTGDKH-----FDKSPTKTRHPRKIDLRARYWAFLFDNLRRAVDEIYVTCESDQSVVECKEVLMM 161
            :|.||.     ..:|..|.::.:|   |||.|....:||:...|.:|..|.|:|||..|||.::.
 Worm     2 STCDKEKAESVVSRSSKKKKNRKK---RARQWTGYVENLKTTCDLMYEMCRSEQSVTGCKEAMLY 63

Human   162 LDNYVRDFKALIDWIQLQEKL---EKTDAQSRPTSLAWEVKK-MSPGRHVIP------------S 210
            |.:...|||:||:.|.::::.   |....|.:..|:||||:| ||.....:|            |
 Worm    64 LQSASNDFKSLIETINVEKQWDQDENRQEQIKRPSVAWEVRKSMSSPNPALPISSIIAEAVKNAS 128

Human   211 PSTDRINVTSNARRSLNFGGSTGTVPAPRLAPTGVSWAD-------KVKAHHTGSTASSEI---- 264
            |.|::.........|.|...:..|. |..:|...||..|       ..:...|.||.:||.
 Worm   129 PPTNKAAEPFPTPSSSNLTYARITA-AAAVAAVAVSQPDDGWKLVTNRRRKSTSSTTASEFDREF 192

Human   265 ------TPAQSCPPMTVQKASRKNERKDAEGWETVQRGRPIRSRSTAVMPKVSLATEATRSKDDS 323
                  .|...||....::.|..:.::.:....|..:......::.|.|.|::.:.:....|
 Worm   193 SVEKEKEPENPCPLNVYERLSSTSYKRTSTRTLTCPKSAMDLPQTRASMAKMAYSRQLLWEK--- 254

Human   324 DKENVCLLPDESIQKGQFVGDGTSNTIESHPKDSLHSCDHPLAEKTQFTVSTLD-DVKNSGSIR- 386
               |..:|.::..|:            :...|.|...|....|:......|..: :.|..||.|
 Worm   255 ---NQQVLVEKLRQR------------QKREKKSNVQCGFTFADPLAVRKSVEEFNQKKIGSRRQ 304

Human   387 --DNYVRTSEISAVHIDTECVSVMLQAGTPPLQVNEEKFPAEKARIENEMDPSDISNVSA----- 444
              :....:|.|....|:.|..:|     .|....|.|..||         ||:..|::|.
 Worm   305 GKETPTTSSNIELHSINEEPTTV-----HPASSENSEDVPA---------DPTPSSSISQPPPTT 355

Human   445 ---ANLSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENNDINIETDNDSDFSAS 506
               ..:.:.|.|.|.:|..:..|:  ||::|   .||..|..||:..|..:|:.|.:...:..|
 Worm   356 TLFGYVQVPEELEKDDEWREMTEE--EESLA---LEENSLNLEIKQAEAMEIDAELERQVEMEA- 414

Human   507 MGSGSVSFCGMSMDWNDVLADYEARESWR-------------------------QNTSWGDIVEE 546
                            |.| :.|.|::.:                         ::.:|.:::|:
 Worm   415 ----------------DKL-EREHRKNQKNLKKEEKKQEKQQEMENFFKVFEEIRSLAWSELMEQ 462

Human   547 EP-----------ARPPGHGIHMHEKLSSPSRKRTIAESK---KKHEEKQMKAQQLREKLREEKT 597
            |.           ...||..:..|||:.||||:|...:..   |:||.||..|::||::|:|.|.
 Worm   463 ESVAQYQLHHHQNVHEPGTHVERHEKMLSPSRRRGHKDDDDFGKRHEMKQKHAEELRQQLQEAKA 527

Human   598 LKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINT 662
            .||::|..|.::||..:|.|.:::|:::|.::..|...|:..:..::::|::::.:|.|:.||.|
 Worm   528 SKLKELTSRVEEVRMKQEALKERKRQLLEARMQRASDNRDKNIMEVIRRAKDDDQRVMEVKFIAT 592

Human   663 LEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQAR---DEAVQERKRALEAE-RQARVEELL 723
            |:..|||:::|:|....|::..:|.:||.|:.|||.|:   .||....:||..|| ||.|:.:|
 Worm   593 LQEDNKRYELLAKDASVEEKQKQLADERARKHEEKAAKKREQEAAATARRAQAAEQRQCRIRKL- 656

Human   724 MKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRH 788
                      .:|::.:...:|:.|.....|..:.|.:|...:.
 Worm   657 ----------SEQKEIRHGKKENPAPSAPEDMLQYLNSLLLTEP--------------------- 690

Human   789 MEQIEQRKEKAAELSSGRHANTDYAPKLTP---YERKKQCSLC---NVLISSEVYLFSHVKGRKH 847
                               .|::..|.|.|   :...:|||||   :.:|.|::...|||...|.
 Worm   691 -------------------VNSEPLPYLWPSTEHLAPRQCSLCSAVSTVIHSDLDAISHVLCSKE 736

Human   848 QQAVRENTSIQGREL-SDEEVEHLSLKKYIIDIVVEST-APAEALKDGEERQKNKKKAKKIKARM 910
            .|       ||.:.| |...:|  .||::...|..|.| ....|:::..:|::...|||....::
 Worm   737 HQ-------IQAKTLTSGSMIE--ELKRHFFGIFKEVTVGDGVAIEEKNQREEAMMKAKAFLGKI 792

Human   911 NF-------------RAKEYES--LMETKNSGSDSPYKAKLQRLAKDLLKQVQVQDSGSWANNKV 960
            ..             |.|....  |...|...:|...:..|::...:|::.|:.....|.|:...
 Worm   793 QLSDSLPAPPSSPRNRTKCVRDFILAHEKLQTNDPKTQEMLEKSLSELVQAVETDWKASTASADA 857

Human   961 SALDRTLGEITRILEKENVADQIAFQAAGGLT--------------------------------A 993
            |:|:  |.:...|...:.:.:.:.....||.|                                .
 Worm   858 SSLN--LEQFCAIQGPQKLLEMLLEWTKGGATLRLCIRVCHVFCVFLKDPRVAYAVIFKPELLKL 920

Human   994 LEHILQ--AVVPATN---------------VNTVLR--IPPKSLCNAI-NVYNLTCN--NCSENC 1036
            .|.||:  |||.|.|               .||..:  ..||:..|:. |..|.:.|  |.|||
 Worm   921 TEKILELVAVVGAENGQNSSENAQNSSENGQNTTKKGQNSPKNAQNSSENAQNSSKNGQNSSEN- 984

Human  1037 SDVLFSNKITFLMDLLIHQLTVYVPDENNTILGRNTNKQVFEGLTTGLLKVSAVVLGCLIANRPD 1101
                                     |:|::...:|::|.                     |....
 Worm   985 -------------------------DQNSSENSQNSSKN---------------------AQNSA 1003

Human  1102 GNCQPATPKI--PTQEMKNKP--SQGDPFNNRVQDLISYVVNMGLIDKLCACFLSVQ-------G 1155
            .|.|.:|..:  |::..:|.|  :|..|.:.::..|      ..|::.|..|..|..       .
 Worm  1004 ENAQNSTRNVQNPSENGQNSPENAQNSPNSQKLPQL------SALLNVLATCLKSAAQRANLPGK 1062

Human  1156 PVDENPKMAIFLQH----AAGLLHAMCTLCFAVTGRSYSIFDNNRQDPTGLTAALQ--------A 1208
            |..::.|....||.    ||..:.|:            |.|..|...|..:...|:        |
 Worm  1063 PTKKHQKEQKELQKLDFLAAQAISAV------------SSFLRNSLSPNDIKLVLRGARGPVLLA 1115

Human  1209 TDLAGVLH----------MLYCVLFHG--------------TILDPSTASPKENYTQNTIQVAIQ 1249
            |.|.|:..          |...||.|.              :|:.|:.:...:|.::|..::.|.
 Worm  1116 TRLLGLAEHSGSAELLGIMGGAVLEHTYELKRAGEPCKELVSIVIPACSGILKNRSENCQKLMIM 1180

Human  1250 SLRFFN-----------SFAALHLPAFQSIVGAEGLSLAFRHMASSL---LGH----CSQVSC-- 1294
            ::....           |...|....:.|:...|.:......|..:|   :.|    |:.:|.
 Worm  1181 AVILLEDAMWSTTQSILSQGNLEERQWGSLTKDEEMLCKLTQMLGNLADGMEHWQKRCTMISWTG 1245

Human  1295 --ESLLHEVIVCVGYFTVNHPDNQVIVQSGRH-----PTVLQKL 1331
              .|.||        ..:||...: ::..|:|     |||.:||
 Worm  1246 GRSSCLH--------ILINHIPIR-LLSIGKHASRLVPTVAEKL 1280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCAPER	XP_047288576.1	SCAPER_N	114..211	CDD:406813	36/112 (32%)
		SMC_N	<370..742	CDD:481474	108/426 (25%)
		Smc	<568..>802	CDD:440809	61/240 (25%)
		ZnF_U1	821..853	CDD:197732	12/34 (35%)
scpr-1	NP_001364617.1	SCAPER_N	27..118	CDD:406813	33/90 (37%)
		Smc	<506..>663	CDD:440809	55/167 (33%)