DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZBTB21 and F56D1.1

DIOPT Version :9

Sequence 1:	NP_001091872.1	Gene:	ZBTB21 / 49854	HGNCID:	13083	Length:	1066	Species:	Homo sapiens
Sequence 2:	NP_495042.3	Gene:	F56D1.1 / 186375	WormBaseID:	WBGene00018959	Length:	454	Species:	Caenorhabditis elegans

Alignment Length:	491	Identity:	95/491 - (19%)
Similarity:	159/491 - (32%)	Gaps:	187/491 - (38%)

- Green bases have known domain annotations that are detailed below.

Human   605 SPASSSHAVLDEKFQRKLIDIVREREIKKALIIKLRRGKPGFQGQSSSQAQQVIKRNL--RSRAK 667
            |.:|||....|::::.:  |...||...|..|               .:.::|.|..:  |.|.:
Worm    10 SSSSSSDEDSDDEYREE--DGNSERSNSKVCI---------------EEVEEVEKEEIASRKRKR 57

Human   668 GA-----YICTYCGKAYRFLSQFKQHIKMHPGEKPLGVNKVAKPKEHAPLASPVENKEVYQCRLC 727
            |.     :.|.:|.|.:|:.::.::|||:|...:                         |||..|
Worm    58 GKTKDEFHPCPFCEKKFRYPNKLREHIKIHDSNR-------------------------YQCLEC 97

Human   728 N--AKLSSLLEQGSHERLCRNAA--VCPYCSLRFFSP---------------------------- 760
            :  .|..:..|..:|.:|..:.|  .||.||.....|
Worm    98 STITKFGTYGELRAHHKLHHSKASHKCPQCSYTNEKPAFIRRHFEQNHVDGIPCTITGCCIKVAK 162

Human   761 -----ELKQEHES------------------KCEYK----------------------------K 774
                 .:|:.|.|                  .||||                            .
Worm   163 NRLKAHIKEYHTSIPLSTEQTRSKLSFNKCPLCEYKPDVSDDDPEQQQKDLEDHVQRIHEEREPA 227

Human   775 LTCLECMRTFKSSFSIWRHQVEVHNQNNMAPTENFSLPVLDHN-----------GDVTGSSRPQS 828
            |..|.| ..:..|.|:..|.....:.....|:.:.|.|.|.::           ..:||:|   |
Worm   228 LCTLGC-GVYLGSGSVSEHLSTCSSLIQNIPSSSQSTPALQNDEWNDANTETTLSTITGTS---S 288

Human   829 QPEPNKVNHIVTTKDDNVFSDSSEQVNFDSE----------------DSSC--LPEDLSLSKQLK 875
            |.|.:.|:.:.....:|: :|..|::.|.:.                |.||  ..:..:|...|:
Worm   289 QFERDSVSEVTNDLSENI-NDIDEEIEFGTTEPPNKIRKHSRSRVHGDFSCEICLKTFTLRDNLR 352

Human   876 IQVKEEPVEEAEEEAPEASTAPKEAGPSKEASLWPCEK---------CGKMFTVHKQLERHQELL 931
            ..|:....|.:::       ..|..|| |....:.|::         |||.|...:.|..|..:.
Worm   353 KHVRVYHSENSQK-------VVKSTGP-KHQEQYKCDRKSKDGDETTCGKTFRTEQALHDHFNVH 409

Human   932 CSVKPFICHVCNKAFRTNFRLWSHFQSHMSQASEES 967
            ..:||:.||.||:.|....|    |..|:|:..:.|
Worm   410 DGIKPYSCHTCNQKFHARDR----FAVHLSKYHQTS 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZBTB21	NP_001091872.1	BTB	20..120	CDD:279045
		Mediates homodimerization	30..96
		BTB	31..120	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..196
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..442
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..485
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..525
		C2H2 Zn finger	548..569	CDD:275368
		zf-C2H2	670..692	CDD:278523	7/21 (33%)
		C2H2 Zn finger	672..692	CDD:275370	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	806..840		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..906		5/26 (19%)
		C2H2 Zn finger	911..931	CDD:275370	7/28 (25%)
		C2H2 Zn finger	939..960	CDD:275370	7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	963..1014		1/5 (20%)
F56D1.1	NP_495042.3	C2H2 Zn finger	67..87	CDD:275368	7/19 (37%)
		C2H2 Zn finger	94..116	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	4/20 (20%)
		C2H2 Zn finger	380..409	CDD:275368	7/28 (25%)
		C2H2 Zn finger	417..434	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100