DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a22 and CYP709B2

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_182218.2	Gene:	CYP709B2 / 819309	AraportID:	AT2G46950	Length:	572	Species:	Arabidopsis thaliana

Alignment Length:	562	Identity:	132/562 - (23%)
Similarity:	223/562 - (39%)	Gaps:	129/562 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLDVVALLLIALAVGF---------------WFVRTRYSYWTRRGIGSEPARFPVGNMEGFRKNK 50
            :|..:.||.|||.:..               |.:..|:.   ::||.....|...||:...||.|
plant    58 LLSTINLLAIALVLLVVPKIYGACRILVWRPWMLSRRFK---KQGISGPKYRILYGNLREIRKMK 119

  Fly    51 H-------------FIDIVTPIYEKFKGN-GAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFE 101
            :             .:..|.|..:::|.. |..|. ::....|.:.::|.|||||||...|..|.
plant   120 NEAKLMVLDPNSNDIVPRVLPHLQQWKSQYGETFL-YWQGTDPRLCISDHELAKQILSNKFVFFS 183

  Fly   102 DRGMYHNERDDP----LTGH-LFRIDGPKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCG 161
                  ..:..|    |:|: |..::|..|...|:.::|.|:..|:|.|           ||:
plant   184 ------KSKTKPEILKLSGNGLIFVNGLDWVRHRRILNPAFSMDKLKLM-----------TQL-- 229

  Fly   162 ELADNAMCGILE---------------IGDLMARYTSDVIGRCAFGVECNGLRNPEAEFAIMGRR 211
             :.|......||               |.....|.|:|:|...|||       :..||    |..
plant   230 -MVDCTFRMFLEWKKQRNGVETEQFVLISREFKRLTADIIATAAFG-------SSYAE----GIE 282

  Fly   212 AFS---ERRHC---KLVDGF---IESFPEVARFLRMRQIHQDITDFYVGIV-RETVKQREEQGIV 266
            .|.   |.:.|   .|.|.:   |:..|..:. |::.::...:......|: .....:.::.|
plant   283 VFKSQLELQKCCAAALTDLYFPGIQYLPTPSN-LQIWKLDMKVNSSIKRIIDARLTSESKDYG-- 344

  Fly   267 RSDFMNLLIEMKQRGE----LTIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREE 327
             :|.:.:::......|    ::|:|:..:...||.||.:|:|:.|.::...|:.....|.|||||
plant   345 -NDLLGIMLTAASSNESEKKMSIDEIIEECKTFFFAGHETTANLLTWSTMLLSLHQDWQEKLREE 408

  Fly   328 IDQAL---RLHNGEFTYDSMQELRYMELVIAETLRKY-PILPQLTRISRHLYAAKGDRHFYIEPG 388
            :....   ::.:.|    :..:|:.|..|..|:||.| |:|..|...|..:...    :..|..|
plant   409 VFNECGKDKIPDAE----TCSKLKLMNTVFMESLRLYGPVLNLLRLASEDMKLG----NLEIPKG 465

  Fly   389 QMLLIPVYGIHHDPALY-PEPHKFIPERFL--ADQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTT 450
            ..:::|:..:|.|.|:: .:..||.|.||.  ..:.|..|.|. |.|..|||.|||..|..|:..
plant   466 TTIILPIAKMHRDKAVWGSDADKFNPMRFANGLSRAANHPNAL-LAFSMGPRACIGQNFAIMEAK 529

  Fly   451 IGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKVQ 492
            ..|..:|:.|..:           |.::....||:.:.|:.|
plant   530 TVLAMILQRFRLN-----------LSADYKHAPADHLTLQPQ 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	121/510 (24%)
CYP709B2	NP_182218.2	p450	89..571	CDD:299894	126/531 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910