DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and tbxas1

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_991172.2	Gene:	tbxas1 / 792041	ZFINID:	ZDB-GENE-030131-8805	Length:	546	Species:	Danio rerio

Alignment Length:	537	Identity:	156/537 - (29%)
Similarity:	263/537 - (48%)	Gaps:	68/537 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VALLLIALAVGFWFVRTRYSYWTRRGIGSEPARFP-VGNMEGFRKNKHFIDIVTPIYEKFKGNGA 68
            |.|.|::|::.:|:..:.:|...|.|| ..|...| :||:..||..  |......:..|:    .
Zfish    22 VCLFLLSLSLLYWYSISPFSNLERCGI-KHPKPLPFIGNLMMFRNG--FFKSQADLINKY----G 79

  Fly    69 PFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFRIDGPKWRPLRQKM 133
            ...|:::..|..|::.|.::.:|:::::|..|.:| |.......|::..|..:.|.:|:.:|..:
Zfish    80 RICGYYIGRRSTVIIADPDMLRQVMVKEFNKFPNR-MTARGITKPMSDSLIMLKGEQWKRVRSIL 143

  Fly   134 SPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGRCAFGVECNGL 198
            :|||::||||.|.|.:....|.|.:.....|::.  ....|......:|.|||...|||.:.:..
Zfish   144 TPTFSAAKMKEMVPLINTATETLLRNLKSHAESE--NSFNIHKCFGCFTMDVIASVAFGTQVDSQ 206

  Fly   199 RNPEAEFAIMGRR--AFSERRHCKLVDGFIESFPEVARFLR---MRQIHQDITDFYVGIVRETVK 258
            .||:..|.....:  |||..|...:   |..:||.:.|.|.   ..:...::..|:...:::.:|
Zfish   207 NNPDDPFVHQASKFFAFSFFRPIMI---FFMAFPFLLRLLAGLLPNKSRDEMNSFFTQCIQKMIK 268

  Fly   259 QRE----EQGIVRSDFMNLLIEMK--------------------------------------QRG 281
            ||:    ||.  |.||:.|:::::                                      |:.
Zfish   269 QRDDLSPEQR--RKDFLQLMLDVRTNKKFLSVEHFDVVNDADEEAYDGHENSPANESTKRSQQKR 331

  Fly   282 ELTIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQE 346
            .:|.:|:..|:|||..||::||::||.|..|.||..|..|.||:||:|:....|. ...|.::||
Zfish   332 MMTEDEIVGQSFIFLVAGYETSSNTLAFTCYLLAVHPECQKKLQEEVDEFFSRHE-TVDYANVQE 395

  Fly   347 LRYMELVIAETLRKYPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKF 411
            |:|:::||.|:||.||...::.|.........|.   ::..|..|.||...:|:||..:.||.||
Zfish   396 LKYLDMVICESLRLYPPAFRVARDVEEDTVLNGQ---FLPKGASLEIPTGFLHYDPEHWTEPTKF 457

  Fly   412 IPERFLADQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLK 476
            |||||..:..|:|....:||||.|||:|:|||..:::..:.||.:.|.|:...|..|:..:| ||
Zfish   458 IPERFTPEAKARRHPFVYLPFGAGPRSCVGMRLAQLEIKVALVHIFRRFNVLACEDTEIPLE-LK 521

  Fly   477 SNILLCPANGIYLKVQQ 493
            |:..|.|.||:.:|:.:
Zfish   522 SHTTLGPKNGVMVKITE 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	146/503 (29%)
tbxas1	NP_991172.2	p450	51..536	CDD:278495	146/503 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.870