Protein Alignment Cyp6a22 and TBXAS1

DIOPT Version :9

• Sequence 1: NP_001286431.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 155/587 - (26%)
• Similarity: 257/587 - (43%)
• Gaps: 128/587 - (21%)

  Fly     5 VALLLIALAVGFWFVRTRYSYWTRRGI-GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKGNGA 68
            |||.:..||:..|:..:.:|...:.|: ..:|:.| :||:..||:.  |.:....:.:.:    .
Human    18 VALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPF-IGNLTFFRQG--FWESQMELRKLY----G 75

  Fly    69 PFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDR---GMYHNERDDPLTGHLFRIDGPKWRPLR 130
            |..|:::..|..:::::.::.||:|:::|:||.:|   |:......|.:   ||..| .:|..:|
Human    76 PLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSV---LFLRD-KRWEEVR 136

  Fly   131 QKMSPTFTSAKMKYMFPTVCEV-------GEELTQ-----------------------VCGELAD 165
            ..:...|:..|:..:...:.:.       |::..|                       .|.....
Human   137 GALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMVPLI 201

  Fly   166 NAMCGIL--------EIGDLM------ARYTSDVIGRCAFGVECNGLRNPEAEFAIMGRRAFSER 216
            :..|.:|        |.||..      ..||:||:...|||...:..:.||..|.
Human   202 SQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFV---------- 256

  Fly   217 RHCKLVDGF---------IESFPEV----ARFLRMRQIHQDITDFYVGIVRETVKQREEQGIV-- 266
            :|||....|         :.|||.:    ||.|..:. ..::..|:..::|..:..|::|...
Human   257 KHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKN-RDELNGFFNKLIRNVIALRDQQAAEER 320

  Fly   267 RSDFMNLLIEMKQRGE-----------------------------------LTIEEMAAQAFIFF 296
            |.||:.::::.:....                                   ||::|:..|||||.
Human   321 RRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFL 385

  Fly   297 AAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNG-EFTYDSMQE-LRYMELVIAETLR 359
            .||::...:||.||.|.||..|..|.||..|:|.....|.. ||.  |::| |.|:::|||||||
Human   386 IAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFC--SLEEGLPYLDMVIAETLR 448

  Fly   360 KYPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQR 424
            .||...:.||.:.......|.|   |..|.:|.:.|..:||||..:|.|..|.||||.|:...|.
Human   449 MYPPAFRFTREAAQDCEVLGQR---IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQH 510

  Fly   425 PTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYL 489
            ....:||||.|||:|:|:|.|.::..:.|:.:|..|.|..||.|...:: |:|...|.|.||:|:
Human   511 RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ-LESKSALGPKNGVYI 574

  Fly   490 KV 491
            |:
Human   575 KI 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	146/554 (26%)
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	146/556 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.920