DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	446	Identity:	136/446 - (30%)
Similarity:	221/446 - (49%)	Gaps:	50/446 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 GFFMMLRPVVLVTDLELAKQILIQD----FANFEDRGMYHNERDDP---LTGHLFRIDGPKWRPL 129
            |.:...:|::::.|.::.|.:|:::    |.|....|        |   |...|...:..:|:.:
Human    73 GLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLG--------PMGFLKSALSFAEDEEWKRI 129

  Fly   130 RQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGRCAFGVE 194
            |..:||.|||.|.|.|.|.:.:.|:.|.:...:.|:|:..  :.:.|....||.|||....|||.
Human   130 RTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKS--INLKDFFGAYTMDVITGTLFGVN 192

  Fly   195 CNGLRNPEAEFAIMGRRAFSERRHCKLVDGF---IESFP---EVARFLRMRQIHQDITDFYVGIV 253
            .:.|.||:..|.    :...:......:|.|   |..||   .|...|.:....:|:|.|    :
Human   193 LDSLNNPQDPFL----KNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHF----L 249

  Fly   254 RETVKQREEQGIV-----RSDFMNLLI------EMKQRGELTIEEMAAQAFIFFAAGFDTSASTL 307
            :.::::.:|..:.     |.||...:|      |.|....|:..|:.||:.|...|.:||:::||
Human   250 KNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTL 314

  Fly   308 GFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTRISR 372
            .|.:||||..|.:|.||:||||..|. :....|||::.::.|:::|:.||||.:|::.::||:.:
Human   315 PFIMYELATHPDVQQKLQEEIDAVLP-NKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCK 378

  Fly   373 HLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPE-RFLADQLAQRPTAAWLPFGDGP 436
            ......|   .:|..|..:::|:|.:||||..:.||.||.|| ||............::|||.||
Human   379 KDIEING---VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGP 440

  Fly   437 RNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNI-LLCPANGIYLKV 491
            ||||||||......:.::..|:||.|..|..|  :|.....|: :|.|...|.|||
Human   441 RNCIGMRFALTNIKLAVIRALQNFSFKPCKET--QIPLKLDNLPILQPEKPIVLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	134/444 (30%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	134/444 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820