Protein Alignment Cyp6a22 and Cyp3a57

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_001093650.1
• Gene: Cyp3a57 / 622127
• MGIID: 3646373
• Length: 503
• Species: Mus musculus
• Alignment Length: 512
• Identity: 146/512 - (28%)
• Similarity: 256/512 - (50%)
• Gaps: 49/512 - (9%)

  Fly     2 LDVVALLLIALAVGFWFVRTRYSYWTRRGIG-SEPARFPV-GN----MEGFRKNKHFIDIVTPIY 60
            |.:...:|:..::.|:::...||:...:.:| ..|...|: ||    ::|..|   |.|   ..|
Mouse     7 LSIQTWVLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGNIINYLDGMWK---FDD---DCY 65

  Fly    61 EKFKGNGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFR----I 121
            :|:    ....||:...:|::.:.|.|:.|.:|::     |...::.|.|.....|.|.:    .
Mouse    66 KKY----GKIWGFYEGPQPILAIMDPEIIKIVLVK-----ECYSVFTNRRPFGPVGFLKKSITIS 121

  Fly   122 DGPKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVI 186
            :..:|:.||..:||||||:|:|.|||.:.:.|:.|.:......:..  ..:.:.|:...|:.|||
Mouse   122 EDEEWKRLRTLLSPTFTSSKLKEMFPIMRQYGDILVRNLRREEEKE--EPINMKDIFGAYSMDVI 184

  Fly   187 GRCAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIES---FP---EVARFLRMRQIHQDI 245
            ...:.||..:.|.||:..|.    :...:....|..|.|:.|   ||   .:...|.:....:..
Mouse   185 TGTSCGVNIDSLNNPQDPFV----QKIKKILKFKFFDPFLLSVVLFPFLTPIYEMLNLSIFPRQS 245

  Fly   246 TDFYVGIVRETVKQREEQGIV-RSDFMNLLIE-MKQRGELTIE-----EMAAQAFIFFAAGFDTS 303
            .:|:...|::..|.|.:.... |.||:.|::. ...:|:.:::     |||||..||...|:|.:
Mouse   246 MNFFKKFVKKMKKDRLDYNQKNRVDFLQLMMNTQNSKGQESLKALSDLEMAAQTLIFIFGGYDGT 310

  Fly   304 ASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLT 368
            ::::.|.:||||..|.:|.||::|||:||. :....|||::.::.|:::|:.|:||.||::.::.
Mouse   311 STSISFIMYELATHPDVQKKLQDEIDRALP-NKAPVTYDALMDMEYLDMVVNESLRLYPVVSRID 374

  Fly   369 RISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFG 433
            |.|:......|   .:|..|.:::||:|.:|.||..:|||..|.||||..:.........::|||
Mouse   375 RFSKKDVEIHG---VFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPERFSKENKGNIDPYIYMPFG 436

  Fly   434 DGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLK 490
            :||||||||||..:...:.:..:|:||....|..|...::..:..|.. |...|.||
Mouse   437 NGPRNCIGMRFALISVKLAVTGVLQNFTVQPCEETQIPVKISRQPIFR-PEKPIILK 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	127/438 (29%)
Cyp3a57	NP_001093650.1	cytochrome_P450	67..492	CDD:477761	129/444 (29%)