Protein Alignment Cyp6a22 and Cyp3a25

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_062766.2
• Gene: Cyp3a25 / 56388
• MGIID: 1930638
• Length: 503
• Species: Mus musculus
• Alignment Length: 528
• Identity: 147/528 - (27%)
• Similarity: 255/528 - (48%)
• Gaps: 79/528 - (14%)

  Fly     2 LDVVALLLIALAVGFWFVRTRYSYWTRRGIG-SEPARFP-VGNMEGFRKNKHFIDIVTPIYEKFK 64
            |.:...:|:..::..:::...||:...:.:| ..|...| :|.:..:.......|  ...|:|:
Mouse     7 LSIETWVLLVTSLVLFYIYGTYSHGLFKKLGIPGPKPLPLLGTIFNYYDGMWKFD--EDCYKKY- 68

  Fly    65 GNGAPFAGFFMMLRPVVLVTDLELAKQILIQD-FANFEDRGMYHNERDDPLTGHLFRIDGP---- 124
               ....||:...:|::.:.|.|:.|.:|::: ::.|.:|                |..||
Mouse    69 ---GKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNR----------------RFFGPVGFM 114

  Fly   125 ----------KWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELT------QVCGELADNAMCGILE 173
                      :|:.||..:||||||.|:|.|||.:.:.|:.|.      :..||        .:.
Mouse   115 KKAITISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGE--------PIS 171

  Fly   174 IGDLMARYTSDVIGRCAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIES---FP---EV 232
            :.|:...|:.|||...:|||..:.|.||:..|....::...    .|:.|.|:.|   ||   .:
Mouse   172 MKDIFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILK----FKIFDPFLLSIILFPFLTPI 232

  Fly   233 ARFLRMRQIHQDITDFYVGIVRETVKQR---EEQGIVRSDFMNLLIE-MKQRGE-----LTIEEM 288
            ...|......:|..:|:...|:...|:|   .::.  |.||:.|::. ...:|:     |:..||
Mouse   233 YEMLNFSIFPRDSMNFFKKFVKRMKKERLASNQKN--RVDFLQLMMNTQNSKGQESQKALSDLEM 295

  Fly   289 AAQAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELV 353
            ||||.||...|:|.:::::...:||||..|.:|.||::|||:.|. :....|||::.::.|:::|
Mouse   296 AAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLP-NKAPVTYDALMDMEYLDMV 359

  Fly   354 IAETLRKYPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLA 418
            :.|:||.|||..:|.|:|:......|   .:|..|.:::||:|.:|.:|..:|||.:|.||||..
Mouse   360 VNESLRLYPIAIRLERVSKKDVEING---VFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSK 421

  Fly   419 DQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCP 483
            :.........::|||:||||||||||..:...:.::.:|:||....|..|...::..:..|.. |
Mouse   422 ENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLKISREPIFQ-P 485

  Fly   484 ANGIYLKV 491
            ...|.|||
Mouse   486 EKPIILKV 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	132/457 (29%)
Cyp3a25	NP_062766.2	CYP3A	67..492	CDD:410743	134/463 (29%)