DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp4f1

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_062569.2	Gene:	Cyp4f1 / 56266	RGDID:	70926	Length:	524	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	135/530 - (25%)
Similarity:	242/530 - (45%)	Gaps:	83/530 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 GIGSEPARFPVGNM--------------------EGFRKNKHF------------IDIVTPIYEK 62
            |:|.|.| ||...:                    ..||:.:.|            :.:|||..:.
  Rat    10 GLGPEVA-FPWQTLLLFGASWILAQILTQIYAAYRNFRRLRGFPQPPKRNWLMGHVGMVTPTEQG 73

  Fly    63 FKG----NGAPFAGFFMMLRPVVLVTDL---ELAKQILIQDFANFEDRGMYHNERDDPLTGHLFR 120
            .|.    .|....||.|.:.|:|.|..|   ::.:.||....|......:::......|...|..
  Rat    74 LKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYTILKPWLGDGLLV 138

  Fly   121 IDGPKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGE-----LADNAMCGILEIGDLMAR 180
            ..|.||...|:.::|.|....:|   |.| ::..:.|.:...     :::.:  ..|::.:.::.
  Rat   139 SAGDKWSRHRRMLTPAFHFNILK---PYV-KIFNDSTNIMHAKWKRLISEGS--SRLDMFEHVSL 197

  Fly   181 YTSDVIGRCAFGVECNGLRNPEAEF--AIMGRRAFSERRHCK---LVDGFIESFPEVARFLRMRQ 240
            .|.|.:.:|.|..:.| .:...:|:  ||:...|...:||.:   .:|......|:..||.:...
  Rat   198 MTLDSLQKCVFSFDSN-CQEKSSEYIAAILELSALVAKRHQQPLLFMDLLYNLTPDGMRFHKACN 261

  Fly   241 IHQDITDFYVGIVRETVKQREEQGI---VRS-------DFMNLLIEMKQRG--ELTIEEMAAQAF 293
            :..:.||   .::||..:...:||:   ::|       ||:::|:..|...  ||:.|::.|:|.
  Rat   262 LVHEFTD---AVIRERRRTLPDQGLDEFLKSKAKSKTLDFIDVLLLTKDEDGKELSDEDIRAEAD 323

  Fly   294 IFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHN-GEFTYDSMQELRYMELVIAET 357
            .|...|.||:||.|.:.||.|||.|..|.:.|:|:.:.||..: .|..:|.:.:|.::.:.|.|:
  Rat   324 TFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRDPEEIEWDDLAQLPFLTMCIKES 388

  Fly   358 LRKYPILPQLTR-ISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQL 421
            ||.:|.:..::| .::.:....|..   |..|.:.||.::||||:|:::|:|..:.|.||..:.:
  Rat   389 LRLHPPVTVISRCCTQDILLPDGRT---IPKGIICLISIFGIHHNPSVWPDPEVYNPFRFDPENI 450

  Fly   422 AQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGL-VSLLRNFHFSVCPRTDPKIEFLKSNILLCPAN 485
            ......|::||..|||||||..|...:..:.| ::|||   |.:.|  |.|....:..::|....
  Rat   451 KDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLR---FRLLP--DDKEPRRQPELILRAEG 510

  Fly   486 GIYLKVQQLS 495
            |::|:|:.||
  Rat   511 GLWLRVEPLS 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	129/519 (25%)
Cyp4f1	NP_062569.2	CYP4F	74..515	CDD:410772	119/458 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000