DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and cyp3c2

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	XP_021330384.1	Gene:	cyp3c2 / 558473	ZFINID:	ZDB-GENE-081103-62	Length:	503	Species:	Danio rerio

Alignment Length:	511	Identity:	147/511 - (28%)
Similarity:	247/511 - (48%)	Gaps:	51/511 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VVALLLIALAVGFWFVRTRYSYWTRRGI-GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKGNG 67
            ||.:|.:....|.|    .:.::.:.|| |..|..| .|....:.|.....|:     |..|..|
Zfish    14 VVLVLTLLYMYGVW----PHGFFKKLGIPGPRPWPF-FGTFLSYTKGFFNFDM-----ECAKKYG 68

  Fly    68 APFAGFFMMLRPVVLVTDLELAKQILIQD-FANFEDRGMYHNERDDPLTGHLFRIDGPKWRPLRQ 131
            ..: |.:....|:::|||||:.|.|:::: ::.|.:|...:.:...||...:..:...:|:.:|.
Zfish    69 KVW-GIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREINVDLAGPLADGITAVKDERWKRIRG 132

  Fly   132 KMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCG----ILEIGDLMARYTSDVIGRCAFG 192
            .:||.|||.::|.:||......:...:       |...|    .::|.::||.|:.||:...||.
Zfish   133 TLSPYFTSGRLKEIFPIAMTHADRFIK-------NMQKGDHEQPVKIKEVMASYSLDVVTSSAFS 190

  Fly   193 VECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIESFPEVARFL---RMRQIHQDITDFYVGIVR 254
            |:.:.:.||:..| :...:.|.:.....|....:..||.:|..|   .:....:...||:...:|
Zfish   191 VDIDSINNPDDPF-VTNIKNFLKFNLFGLFVLLLTVFPSIANLLGKMGLSMFSKPTVDFFYKALR 254

  Fly   255 ETVKQREEQGIVRSDFMNLLI--------------EMKQRGELTIEEMAAQAFIFFAAGFDTSAS 305
            : :|:..:....|.||..|:|              |..::| ||..|:.:|:|||...|::|:::
Zfish   255 K-IKEEHKDSNGRVDFFRLMIQNEIPDDQVKDTTSEQPEKG-LTDHEILSQSFIFIMGGYETTST 317

  Fly   306 TLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTRI 370
            ||.|.||.||..|....||.|:||:...| :...:||::.::.|:|:.|.|::|..|..|:|.|:
Zfish   318 TLTFLLYNLAINPDCLEKLVEKIDKNFPL-DTPISYDALMKIDYLEMSINESMRLLPTAPRLERV 381

  Fly   371 SRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFGDG 435
            .:......|   ..|....|:.||.|.::.||.|:..||:|.||||..:..::....|::|||.|
Zfish   382 CKKTVEMNG---ITIPKDTMITIPTYVLNQDPQLWDSPHEFRPERFSPENKSEFLQYAFMPFGLG 443

  Fly   436 PRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKV 491
            ||||||||:..|...:.:|.||:||....|..|...:|.   |.:..|...|.||:
Zfish   444 PRNCIGMRYALMIVKLLVVKLLQNFSVETCKETQIPLEL---NPVFQPKVPITLKL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	138/477 (29%)
cyp3c2	XP_021330384.1	p450	38..496	CDD:306555	139/481 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910