Protein Alignment Cyp6a22 and cyp3a65

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_001032515.2
• Gene: cyp3a65 / 553969
• ZFINID: ZDB-GENE-050604-1
• Length: 517
• Species: Danio rerio
• Alignment Length: 519
• Identity: 151/519 - (29%)
• Similarity: 243/519 - (46%)
• Gaps: 52/519 - (10%)

  Fly     4 VVALLLIALAVGFWFVRTRYSYWTRRGIGSEPARFP-VGNMEGFRKNKHFIDIVTPIYEKFKGNG 67
            :||||:|   .|.|    .:.|:.:.||.. |...| .|.|..::...|..|:  ..:||:
Zfish    14 LVALLVI---YGSW----PHRYFKKLGIPG-PKTIPFFGTMLRYKDGFHVFDM--DCFEKY---- 64

  Fly    68 APFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFR----IDGPKWRP 128
            ....|.:...:||:.:.|..:.|.:||:     |...::.|.|:..|.|.|:.    .:...||.
Zfish    65 GRIWGIYDGRQPVLCIMDQTIIKTVLIK-----ECYSLFTNRRNFRLNGALYDAVSIAEDDDWRR 124

  Fly   129 LRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGRCAFGV 193
            :|..:||:|||.::|.||..:.:....|....|:.|......  :|.:....|:.||:...||.|
Zfish   125 IRSVLSPSFTSGRLKEMFGIMKKHSHILVDSMGKTAKRGESA--DIKEFFGAYSMDVVTSTAFSV 187

  Fly   194 ECNGLRNPEAEFA--IMGRRAFSERRHCKLVDGFIESFPEVARFLRMRQIHQDITDFYVGIVRET 256
            :.:.|.||:..|.  |.....|.......|:..|......|...:........:|||:...:::.
Zfish   188 DIDSLNNPKDPFVTNIKKMLKFDLLNPLFLLIAFFPFMAPVLEKMDFALFPTSVTDFFYAALQKI 252

  Fly   257 VKQREEQGIV------RSDFMNLLIEM------KQRGE-----LTIEEMAAQAFIFFAAGFDTSA 304
            ...|:.:.:.      |.||:.|:::.      |..||     |:..|:.:|:.||..||::||:
Zfish   253 KSDRDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDGEHTEKGLSDHEILSQSMIFIFAGYETSS 317

  Fly   305 STLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTR 369
            |||.|..|.||..|....||:||||:... :.....|:::..:.|::..::|:||.||:..:|.|
Zfish   318 STLSFLFYNLATNPETMKKLQEEIDETFP-NQAPVDYETLMSMDYLDAALSESLRLYPVAARLER 381

  Fly   370 ISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFGD 434
            :.:......|   ..|....::::|.|.:|.||..:.||..|.||||............::|||.
Zfish   382 VCKKTVEING---LLIPKDLVVMVPTYALHRDPDYWSEPESFKPERFTKGNKESIDPYMYMPFGL 443

  Fly   435 GPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKVQ--QLSQ 496
            ||||||||||.::...:.:|.:|:.|..|||..|...:| |..|.||.|.:.|.||:|  :|||
Zfish   444 GPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLE-LGFNGLLSPKDPIKLKLQPRKLSQ 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	126/444 (28%)
cyp3a65	NP_001032515.2	cytochrome_P450	63..498	CDD:477761	128/450 (28%)