Protein Alignment Cyp6a22 and cyp3a4.2

DIOPT Version :9

• Sequence 1: NP_001286431.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_001015786.1
• Gene: cyp3a4.2 / 548503
• XenbaseID: XB-GENE-971750
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 526
• Identity: 161/526 - (30%)
• Similarity: 248/526 - (47%)
• Gaps: 84/526 - (15%)

  Fly     4 VVALLLIALAVGFWFVRTRYSYWTRRGI-GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKGNG 67
            :.|||::.|..|.|    .|.|:.:.|| |..|..| :|....|||.  .:...|..::|:....
 Frog    15 LAALLVLILLYGIW----PYGYFKKMGIPGPTPLPF-IGTFLEFRKG--MVQFDTECFKKYGKMW 72

  Fly    68 APFAGFFMMLRPVVLVTDLELAKQILIQD-FANFEDRGMYHNERDDPLTGHLFRIDGP------- 124
            ..:.|    .:||:.:.|..:.|.||::: :.||.:|             ..|.::||
 Frog    73 GTYDG----RQPVLAIMDPAIIKTILVKECYTNFTNR-------------RNFGLNGPFESAITI 120

  Fly   125 ----KWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQ-VCGELADNAMCGILEIGDLMARYTSD 184
                :|:.:|..:||||||.|:|.||..:.:..:.|.: :.|.:..:..|.   ..|::..|:.|
 Frog   121 AEDEQWKRIRNVLSPTFTSGKLKEMFQIMKDYSDILVKNIQGYVEKDEPCA---TKDVIGAYSMD 182

  Fly   185 VIGRCAFGVECNGLRNPEAEFAIMGRRAFSERRHCK--LVDGFIES-------FP---EVARFLR 237
            ||...:|.|..:.|..|...|.|          |.|  |..|.:..       ||   .:...|.
 Frog   183 VITSTSFSVNIDSLNKPSDPFVI----------HMKKLLKTGLLSPLLILVVIFPFLRPILEGLN 237

  Fly   238 MRQIHQDITDFYVGIV---RETVKQREEQGIVRSDFMNLLIEMKQRG---------ELTIEEMAA 290
            :..:.:|.|:|::..|   ||..|:.:..|  |.|.:.|:::.:..|         .||..|:.|
 Frog   238 LNFVPKDFTEFFMNAVTSFREKRKKGDHSG--RVDLLQLMMDSRTTGGNDLSNKHKALTDAEIMA 300

  Fly   291 QAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIA 355
            |:.||..||::|:::.|.:..|.||..|.:|.:|.||||..|. .....|||.:.::.|:::||.
 Frog   301 QSVIFIVAGYETTSTALSYLFYNLATHPDVQQRLHEEIDSFLP-DKASPTYDILMQMEYLDMVIQ 364

  Fly   356 ETLRKYPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQ 420
            ||||.:|...:|.|:|:......|   ..|..|.:.|||.|.:..||..:|||.:|.||||..:.
 Frog   365 ETLRLFPPAGRLERVSKQNVEING---VSIPKGIVTLIPAYVLQRDPEYWPEPEEFRPERFSKEN 426

  Fly   421 LAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNI-LLCPA 484
            .|......:||||||||||||:||..:...:.:|:||:||....|..|...:||  |.| .|.|.
 Frog   427 RATHTPFTFLPFGDGPRNCIGLRFALLSMKVAIVTLLQNFSVRPCAETLIPMEF--STIGFLQPK 489

  Fly   485 NGIYLK 490
            ..|.||
 Frog   490 KPIVLK 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	150/494 (30%)
cyp3a4.2	NP_001015786.1	p450	39..496	CDD:365848	151/498 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	239	1.000	Domainoid score	I2234
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3174
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060