DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp3a41a

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_059092.2	Gene:	Cyp3a41a / 53973	MGIID:	1858451	Length:	504	Species:	Mus musculus

Alignment Length:	523	Identity:	162/523 - (30%)
Similarity:	253/523 - (48%)	Gaps:	70/523 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LDVVALLLIALAVGFWFVRTRYSYWTRRGI-GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKG 65
            ||...||.|.|.:.:.:....:..:.::|| |.:|..| :|.:..:.|.....|:  ..|||:
Mouse     9 LDTWVLLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPF-LGTVLNYYKGLWKFDM--ECYEKY-- 68

  Fly    66 NGAPFAGFFMMLRPVVLVTDLELAKQILIQD-FANFEDRGMYHNERDDPLTGHLFRIDGP----- 124
             |..: |.|....|:.::||.|:.|.:|::: |:.|.:|                |..||
Mouse    69 -GKTW-GLFDGQMPLFVITDPEMIKNVLVKECFSVFTNR----------------REFGPVGIMS 115

  Fly   125 ---------KWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMAR 180
                     :|:..|..:||||||.|:|.|||.:.:.|:.|.:...:.|:...  .:.:.|::..
Mouse   116 KAISISKDEEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEKGK--PVTMKDVLGA 178

  Fly   181 YTSDVIGRCAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGF------IESFP---EVARFL 236
            |:.|||...:|||..:.|.|||..|.       .:.:....||.|      :..||   .|...|
Mouse   179 YSIDVITSTSFGVNVDSLNNPEDPFV-------EKAKGILRVDFFDPLVFSVVLFPFLTPVYEML 236

  Fly   237 RMRQIHQDITDFYVGIVRETVKQR-EEQGIVRSDFMNLLIEMKQRGE-------LTIEEMAAQAF 293
            .:....:|..:|:...|....:.| :.:...|.||:.|::......:       |:..|:.||:.
Mouse   237 NICMFPKDSIEFFKKFVNRMKESRLDSKQKHRVDFLQLMMNAHNNSKDKDSHKALSDMEITAQSI 301

  Fly   294 IFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETL 358
            :|..||::|::|||.|.||.||..|.:|.||:||||:.|. :....|||::.|:.|:::|:.|||
Mouse   302 VFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLP-NKAPPTYDTVMEMEYLDMVLNETL 365

  Fly   359 RKYPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQ 423
            |.|||..:|.|..:......|   .||..|..::||.|.:||||..:|||.:|.||||..:....
Mouse   366 RLYPIGNRLERFCKKDVELNG---VYIPKGSTVMIPSYALHHDPQHWPEPEEFQPERFSKENKGS 427

  Fly   424 RPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIY 488
            .....::|||.||||||||||..|...:.|..:::||.|..|..|...::..:.. ||.|...|.
Mouse   428 IDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQIPLKLSRQG-LLQPEKPIV 491

  Fly   489 LKV 491
            |||
Mouse   492 LKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	151/487 (31%)
Cyp3a41a	NP_059092.2	p450	39..494	CDD:278495	152/491 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820