Protein Alignment Cyp6a22 and Cyp3a73

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: XP_038945885.1
• Gene: Cyp3a73 / 498198
• RGDID: 1595705
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 523
• Identity: 156/523 - (29%)
• Similarity: 246/523 - (47%)
• Gaps: 70/523 - (13%)

  Fly     2 LDVVALLLIALAVGFWFVRTRYSYWTRRGI-GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKG 65
            |:...||.|.|.:.:.|....:..:.::|| |.:|..| :|.:..:.:.....|:     |.:|.
  Rat     9 LETWLLLAIILVLFYRFGTRTHGIFKKQGIPGPKPLPF-LGTVLNYYRGLWKFDM-----ECYKK 67

  Fly    66 NGAPFAGFFMMLRPVVLVTDLELAKQILIQD-FANFEDRGMYHNERDDPLTGHLFRIDGP----- 124
            .|..: |.|....||..:.|.|:.|.:|::: |:.|.:|                |..||
  Rat    68 CGKIW-GLFDGQTPVFAIMDTEMIKSVLVKECFSVFTNR----------------RNIGPVGIMS 115

  Fly   125 ---------KWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMAR 180
                     :|:..|..:||||||.::|.|||.:...|:.|.:...:..:...  .|.:.::...
  Rat   116 KSISVAKDEEWKRYRAFLSPTFTSGRLKEMFPIIEHYGDILVKYLKQKVEKGK--PLAMKEVFGA 178

  Fly   181 YTSDVIGRCAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIESFPEVARFLRMRQIHQ-- 243
            |:.|||...:|.|..|.:.||:..|.       .:.:..:..|.|...|..|..|..:..|::
  Rat   179 YSMDVITSTSFEVNINSINNPKDPFV-------EKVKKFQRFDFFDPLFLSVVLFPFLTPIYEML 236

  Fly   244 -------DITDFYVGIVRETVKQR-EEQGIVRSDFMNLLIEMKQRGE-------LTIEEMAAQAF 293
                   |...|:...|....:.| :.:...|.||:.|::......:       |:..|:.|||.
  Rat   237 NICLFPKDSVAFFQKFVYRMKQTRLDSKHKHRVDFLQLMMNAHNNSKDKVSHKALSDIEIVAQAI 301

  Fly   294 IFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETL 358
            ||..|.::|::|||.|.||.||..|..|.||:||||:||. :....|||::.|:.|:::|:.||.
  Rat   302 IFIFASYETTSSTLSFVLYSLATHPDSQKKLQEEIDRALP-NKAPPTYDTVMEMEYLDMVLNETP 365

  Fly   359 RKYPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQ 423
            |.|||..:|.|:.:......|   .:|..|.:::||.|.:.|||..:|||.:|:||||..:....
  Rat   366 RLYPIGYRLERVCKKDIKLDG---VFIPKGSVVMIPFYTLQHDPQHWPEPEEFLPERFSKENKGS 427

  Fly   424 RPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIY 488
            .....:||||:||||||||||..|...:.|..:|:||.|.:|..|...:: |....|..|...|.
  Rat   428 IDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQLCEETQIPLK-LSRQRLFGPEKPIV 491

  Fly   489 LKV 491
            |||
  Rat   492 LKV 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	137/453 (30%)
Cyp3a73	XP_038945885.1	CYP3A	67..493	CDD:410743	138/456 (30%)