DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	156/518 - (30%)
Similarity:	261/518 - (50%)	Gaps:	40/518 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ALLLIALAVGFWFVRTRYSYWTRRGIGSEPARFPVGNMEG-FRKNKHFIDIVTPIYEKFKGNGAP 69
            ||..||.|:.:.:......::..|||..|......|||.| |.:.:...|||..:|.  ||....
  Fly     7 ALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYT--KGGSKK 69

  Fly    70 FAGFFMMLRPVVLVTDLELAKQILIQDFANF-EDRGMYHNERDDP------LTG-HLFRIDGPKW 126
            |.|.|...:|:::|.|.:|.|||.|:||.:| ..|.::....||.      |.| .||.:...:|
  Fly    70 FFGIFEQRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMRDARW 134

  Fly   127 RPLRQKMSPTFTSAKMKYMFPTVCEVGEE----LTQVCGELADNAMCGILEIGDLMARYTSDVIG 187
            :.:|..:||.||.:||:.||..:.:|.:|    |.|....:.:|.    |::.|...|:|:|||.
  Fly   135 KDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENE----LDMKDYCTRFTNDVIA 195

  Fly   188 RCAFGVECNGLRNPEAEFAIMGRR--AFSERRHCKLVDGFIESFPEVARFLRMRQIHQDITDFYV 250
            ..|||::.|..::.|..|..||::  .|:..:..|.:..|  :...:.:.|::....:..|.::|
  Fly   196 STAFGLQVNSFKDRENTFYQMGKKLTTFTFLQSMKFMLFF--ALKGLNKILKVELFDRKSTQYFV 258

  Fly   251 GIVRETVKQREEQGIVRSDFMNLLIEMKQRGELTIE-------------EMAAQAFIFFAAGFDT 302
            .:|.:.:|.|:|..|||.|.:|:|  |:.||.:..|             ::.||.|:||.|||:|
  Fly   259 RLVLDAMKYRQEHNIVRPDMINML--MEARGIIQTEKTKASAVREWSDRDIVAQCFVFFFAGFET 321

  Fly   303 SASTLGFALYELAKQPALQAKLREEIDQALR-LHNGEFTYDSMQELRYMELVIAETLRKYPILPQ 366
            ||..:.|..:||.:...:|.:|.||:.|..: |...|.||:::..::|::.|:.|.|||:|....
  Fly   322 SAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGKELTYEAIMGMKYLDQVVNEVLRKWPAAIA 386

  Fly   367 LTR-ISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWL 430
            :.| .::.:......:...::.|.::.:|..|.|.||..:..|.||.||||..:.........:.
  Fly   387 VDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQPFTYF 451

  Fly   431 PFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKVQQ 493
            |||.|.|||||.||..::....:..||:::.|:...::...:|.:.|...|.|..|.::|:.|
  Fly   452 PFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWIKLVQ 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	145/485 (30%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	145/483 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461239
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900