Protein Alignment Cyp6a22 and CYP4F3

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 395
• Identity: 115/395 - (29%)
• Similarity: 198/395 - (50%)
• Gaps: 37/395 - (9%)

  Fly   123 GPKWRPLRQKMSPTFTSAKMK-YMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVI 186
            |.||...|:.::|.|....:| ||  .:......:.....:|..:.....|::.:.::..|.|.:
Human   141 GEKWSRHRRMLTPAFHFNILKPYM--KIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSL 203

  Fly   187 GRCAFGVECNGLRNPEAEF--AIMGRRAFSERRHCKL---VDGFIESFPEVARFLRMRQIHQDIT 246
            .:|.|..:.:....| :|:  ||:...|...:||.::   :|......|:..||.|..::..|.|
Human   204 QKCVFSFDSHCQEKP-SEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFT 267

  Fly   247 DFYVGIVRETVKQREEQGI-------VRS---DFMNLLIEMKQRG--ELTIEEMAAQAFIFFAAG 299
            |   .:::|..:....||:       .:|   ||:::|:..|...  :|:.|::.|:|..|...|
Human   268 D---AVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEG 329

  Fly   300 FDTSASTLGFALYELAKQPALQAKLREEIDQALR-LHNGEFTYDSMQELRYMELVIAETLRKYPI 363
            .||:||.|.:.||.|||.|..|.:.|:|:.:.|: ....|..:|.:.:|.::.:.|.|:||.:|.
Human   330 HDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPP 394

  Fly   364 LPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAA 428
            :|.::|...........|  .|..|.:.||.|:|.||:||::|:|..:.|.||....:.:|...|
Human   395 VPAVSRCCTQDIVLPDGR--VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLA 457

  Fly   429 WLPFGDGPRNCIGMRF--GKMQTTIGLVSLLRNFHFSVCP-RTDPKIEFLKSNILLCPANGIYLK 490
            ::||..|||||||..|  .:|:..:|| :|||   |.|.| .|:|:   .|..::|....|::|:
Human   458 FIPFSAGPRNCIGQAFAMAEMKVVLGL-TLLR---FRVLPDHTEPR---RKPELVLRAEGGLWLR 515

  Fly   491 VQQLS 495
            |:.||
Human   516 VEPLS 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	111/386 (29%)
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	111/388 (29%)