DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp9f3

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001350862.1	Gene:	Cyp9f3 / 3772405	FlyBaseID:	FBgn0038034	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	133/522 - (25%)
Similarity:	230/522 - (44%)	Gaps:	125/522 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DVVALLLIALAVGFWFVRTRYSYWTRRGIGSEPARFPVGNMEG-FRKNKHFIDIVTPIYEKFKGN 66
            :.:||..||.|:.:.:......::..|||..|.....:|||.| |.:.:..:|||..:|.  ||.
  Fly     4 EFLALFAIATALFYRWASANNDFFKDRGIAYEKPVLYLGNMAGMFLRKRAMLDIVCDLYT--KGG 66

  Fly    67 GAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNE-----RDDP------LTGHLFR 120
            ...|.|.|...:|:::|.|.:|.|||.|:||.:|.:   :.||     .|||      .:..||.
  Fly    67 SGKFFGIFAQRQPLLMVRDPDLIKQITIKDFDHFIN---HRNEFDTSSDDDPHDMSNLFSSSLFS 128

  Fly   121 IDGPKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEE----LTQVCGELADNAMCGILEIGDLMARY 181
            :...:|:.:|..:||.||.:||:.||..:.:|.:|    |.|....:.:|.    |::.|...|:
  Fly   129 MRDARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENE----LDMKDYCTRF 189

  Fly   182 TSDVIGRCAFGVECNGLRNPEAEFAIMGRR--AFSERRHCKLVDGFIESFPEVARFLRMRQIHQD 244
            |:|||...|||::.|..::.|..|..||::  .|:..::.|.:  .:.:...:.:.|::....:.
  Fly   190 TNDVIASTAFGLQVNSFKDRENTFYQMGKKLTTFTFLQNMKFI--LLFALKSLNKILKVEIFDRK 252

  Fly   245 ITDFYVGIVRETVKQREEQGIVRSDFMNLLIEMKQRGELTIE-------------EMAAQAFIFF 296
            .|.::|.:|.:.:|.|:|..|||.|.:|:|  |:.||.:..|             ::.||.|:||
  Fly   253 STQYFVRLVLDAMKYRQEHNIVRPDMINML--MEARGIIQTEKTKASAVREWSDRDIVAQCFVFF 315

  Fly   297 AAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKY 361
            .|||:|||..:.|..:||.:...:|.:|.||:.|..:...|       :||:|::.|::|.|||:
  Fly   316 FAGFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEG-------KELKYLDQVVSEVLRKW 373

  Fly   362 PILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPT 426
            |                                                              |.
  Fly   374 P--------------------------------------------------------------PA 376

  Fly   427 AAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKV 491
            .|:      .|.|      ..:....:..||:::.|:...::...:|.:.|...|.|..|.::|:
  Fly   377 IAF------DREC------NKEAKAVIYYLLKDYRFAPAKKSCIPLELISSGFQLSPKGGFWIKL 429

  Fly   492 QQ 493
            .|
  Fly   430 VQ 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	122/486 (25%)
Cyp9f3	NP_001350862.1	p450	36..>388	CDD:325183	114/445 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461251
Domainoid	1	1.000	171	1.000	Domainoid score	I2249
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	8.000