DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp6t3

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	155/512 - (30%)
Similarity:	249/512 - (48%)	Gaps:	39/512 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLDVVALLLIALAVGFWFVRTRYSYWTRRGIGSEP--ARFPVGNM-EGFRKNKHFIDIVTPIYEK 62
            ||.:..|||..:.:.|| :|.:|.|:..|||...|  :..|:||: :.......|.|:...:|..
  Fly     1 MLLIWLLLLTIVTLNFW-LRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLYAD 64

  Fly    63 FKGNGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDP---LTGHLFRIDGP 124
            .:...|...|||:...|.::|.|.||.:|:||::|.||.:| ....:..||   ||..|.:..
  Fly    65 PRNGQAKIVGFFIFQTPALMVRDPELIRQVLIKNFNNFLNR-FESADAGDPMGALTLPLAKYH-- 126

  Fly   125 KWRPLRQKMSPTFTSAKMK-YMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGR 188
            .|:..||.||..|||.:|: .|:..:.:|..:|.|.......:.:..:|.:|.:...||:||.|.
  Fly   127 HWKESRQCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLPLGRMCQLYTTDVTGN 191

  Fly   189 CAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIESF--PEVARFLRMRQIHQDITDFYVG 251
            ..:.:...|||...:|.....:..|:.... |::| |:..|  |:....|:.:...:|    |..
  Fly   192 LFYSLNVGGLRRGRSELITKTKELFNTNPR-KVLD-FMSVFFLPKWTGVLKPKVFTED----YAR 250

  Fly   252 IVRETVKQREEQGIVRSDFMNLLIEMKQRGELTIEE---------MAAQAFIFFAAGFDTSASTL 307
            .:|..|....|.  .:.|.:|.|    |..:|:...         :|:||.|...|||:||::.:
  Fly   251 YMRHLVDDHHEP--TKGDLINQL----QHFQLSRSSNHYSQHPDFVASQAGIILLAGFETSSALM 309

  Fly   308 GFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYP----ILPQLT 368
            ||.||||||.|.:|.:||.|:.:|. :.....:||::..|.|:::|..|.||.||    :..:.|
  Fly   310 GFTLYELAKAPDIQERLRSELREAF-ISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECT 373

  Fly   369 RISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFG 433
            ..:...::.:....|.:.||....|.:.|:|.|...:|||..|.||||..::........::|||
  Fly   374 SSASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPFG 438

  Fly   434 DGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLK 490
            .||..|||.|.|.:|..:|:|.:|:.:....|.||..:|.|...:.:|...|.|||:
  Fly   439 AGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYLR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	142/478 (30%)
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	137/467 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461083
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900