DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp6a13

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	499	Identity:	228/499 - (45%)
Similarity:	328/499 - (65%)	Gaps:	13/499 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VVALLLIALAVGFWF---VRTRYSYWTRRGIGSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKG 65
            ::.||::...||...   :|..||||:|||:..|...:..|||.|..::.|:.||...||.||:|
  Fly     1 MLTLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIYRKFRG 65

  Fly    66 NGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFRIDGPKWRPLR 130
             ...:.|:|..:...:.:.||||.:.|:|:||::|.|||::||.|||||||:|..:|||:||.||
  Fly    66 -VERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDPLTGNLLFLDGPEWRWLR 129

  Fly   131 QKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGRCAFGVEC 195
            |.::..|||.|||:|||.:.||||:|||.|     ....|.:|..||.||:|:||||.||||:||
  Fly   130 QNLTQVFTSGKMKFMFPNMVEVGEKLTQAC-----RLQVGEIEAKDLCARFTTDVIGSCAFGLEC 189

  Fly   196 NGLRNPEAEFAIMGRRAFSERRHCKLVDGFIESFPEVARFLRMRQIHQDITDFYVGIVRETVKQR 260
            |.|::||::|..|||....|..|..||..|:.:.||:||.||.|....::::|::..||:|:..|
  Fly   190 NSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDTVRQTLDYR 254

  Fly   261 EEQGIVRSDFMNLLIEMKQRG---ELTIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQA 322
            ..:.|.|:|.:.||:|:.:.|   .|:.|::||||.:||.||||||::|:.|.|||||..|.:|.
  Fly   255 RRENIHRNDLIQLLMELGEEGVKDALSFEQIAAQALVFFLAGFDTSSTTMSFCLYELALNPDVQE 319

  Fly   323 KLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTRISRHLYAAKGDRHFYIEP 387
            :||.|:...|:.:|.:.||||:||:.|::.|:|||||||||||.|.|.|...|... :.:..:||
  Fly   320 RLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEYQIP-NSNLILEP 383

  Fly   388 GQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIG 452
            |..::|||:.|||||.|||:|.||.|.||..:::..|...|:||||:|||||||.||||:|..:|
  Fly   384 GSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGPRNCIGERFGKLQVKVG 448

  Fly   453 LVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKVQQLSQ 496
            ||.|||:|.||...:|...::|...|.|:....|::|:::.|.:
  Fly   449 LVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRMEGLER 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	214/458 (47%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	212/449 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471796
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900