DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a22 and Cyp9b2

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	150/506 - (29%)
Similarity:	246/506 - (48%)	Gaps:	35/506 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VALLLIALAVGFWFVRTRYSYWTRRGIGSEPARFPVGNMEGFRKNK-HFIDIVTPIYEKFKGNGA 68
            :||::|...:..|...|..::..|:....:|..| ||||......| .|...:|..||:.:.:
  Fly     8 LALVVIGYLIYKWSTATFKTFEERKLYFEKPYPF-VGNMAAAALQKSSFQRQLTEFYERTRQH-- 69

  Fly    69 PFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFRIDGPKWRPLRQKM 133
            ...|||.|..|::.:.|.||.|::.::||.:|.:...:....|......|..:...:|:.:|..:
  Fly    70 KLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFITSNDRLFNDMLSVMRDQRWKHMRNTL 134

  Fly   134 SPTFTSAKMKYMFPTVCEVGEELTQVCG------------ELADNAMCGILEIGDLMARYTSDVI 186
            :|.||:|||:.||..:.|...|..|...            |:....||.         :.::|:|
  Fly   135 TPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFEVDMKVMCN---------KLSNDII 190

  Fly   187 GRCAFGVECNGLRNPEAEFAIMGRR-AFSERRHCKLVDGFIESF-PEVARFLRMRQIHQDITDFY 249
            ...|||::.|...||:.||..:|:. .||  |..:.....:.:. |::...|::........|::
  Fly   191 ATTAFGLKVNSYDNPKNEFYEIGQSLVFS--RGLQFFKFMLSTLVPKLFSLLKLTIFDSAKVDYF 253

  Fly   250 VGIVRETVKQREEQGIVRSDFMNLLIEMKQRGE--LTIEEMAAQAFIFFAAGFDTSASTLGFALY 312
            ..:|.|.::.||:..|.|.|.:.||:|.|...|  .|.:|:.||.||||.|.|:.:::.:....|
  Fly   254 ARLVVEAMQYREKHNITRPDMIQLLMEAKNESEDKWTDDEIVAQCFIFFFAAFENNSNLICTTTY 318

  Fly   313 ELAKQPALQAKLREEIDQALRLHNG-EFTYDSMQELRYMELVIAETLRKYPILPQLTRISRHLYA 376
            ||...|.:|.:|.|||.:..:..|| ..|||::|::.||::||:|:|||:.:.....|:....|.
  Fly   319 ELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVISESLRKWTLAAATDRLCSKDYT 383

  Fly   377 A---KGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFGDGPRN 438
            .   .|.:.|..:.|..:.||:.|:|.|...:|||.||.|:||..::........:||||.||||
  Fly   384 LTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSEERKGDMVPYTYLPFGVGPRN 448

  Fly   439 CIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYL 489
            |||.|:..||....|.:||.::.....|||...:....|.....|.:|.::
  Fly   449 CIGNRYALMQVKGMLFNLLLHYKIEASPRTIKDLWGSASGFNFTPRSGFWM 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	144/476 (30%)
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	139/454 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461263
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900