DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp6u1

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	169/492 - (34%)
Similarity:	260/492 - (52%)	Gaps:	22/492 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ALAVGFWFVRTRYSYWTRRGIGSEPARFPVGNMEGFRKNK-HFIDIVTPIYEKFKGNGAPFAGFF 74
            ||:|.:..|:....||.||||..|..:|..||::|....| |..|.:..||..:||. |||.||:
  Fly    14 ALSVVYALVKFSLGYWKRRGILHEKPKFLWGNIKGVVSGKRHAQDALQDIYTAYKGR-APFVGFY 77

  Fly    75 MMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFRIDGPKWRPLRQKMSPTFTS 139
            ..|:|.:|..||:|..||:..|..:|..||:|.|...:||:.:|.::||.|||.|..|.:..||.
  Fly    78 ACLKPFILALDLKLVHQIIFTDAGHFTSRGLYSNPSGEPLSHNLLQLDGHKWRSLHAKSAEVFTP 142

  Fly   140 AKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGRCAFGVECNGLRNPEAE 204
            |.|:.:...:.::...:.:..||.:    ...:.|.:|:..|.:||:...|||:    :.....|
  Fly   143 ANMQKLLVRLSQISSRIQRDLGEKS----LQTINISELVGAYNTDVMASMAFGL----VGQDNVE 199

  Fly   205 FAIMGRRAFSERRHCKLVDGFIE-SFPEVARFLRMRQIHQDITDFYVGIVRETV---KQREEQGI 265
            ||...|..:::.|   :...::. .||.:||.|:.:...:..|.::..:....:   ::|:.|.:
  Fly   200 FAKWTRNYWADFR---MWQAYLALEFPLIARLLQYKSYAEPATAYFQKVALSQLQLHRRRDRQPL 261

  Fly   266 VRSDFMNLLIEMKQRGELTIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQ 330
              ..|:.|....::  .||..|:|.|||.|..||.....:||.|.|||||:||.:|.:.|.||::
  Fly   262 --QTFLQLYSNAEK--PLTDIEIAGQAFGFVLAGLGPLNATLAFCLYELARQPEVQDRTRLEINK 322

  Fly   331 ALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPV 395
            ||..|.|:.|.:.::||||.:.|:.||||.:...|.|.|.:...:...|. .|.|..|..:|||.
  Fly   323 ALEEHGGQVTPECLRELRYTKQVLNETLRLHTPHPFLLRRATKEFEVPGS-VFVIAKGNNVLIPT 386

  Fly   396 YGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNF 460
            ..||.||.:|..|.:|.||||.......||.||:||||||.|.||..||.:.|..:|||:|||..
  Fly   387 AAIHMDPGIYENPQRFYPERFEEQARRSRPAAAFLPFGDGLRGCIAARFAEQQLLVGLVALLRQH 451

  Fly   461 HFSVCPRTDPKIEFLKSNILLCPANGIYLKVQQLSQM 497
            .::....|...:|:....:||.|.:.|.|.|:::.::
  Fly   452 RYAPSAETSIPVEYDNRRLLLMPKSDIKLSVERVDKL 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	157/460 (34%)
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	154/453 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471841
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900