DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp6w1

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	179/526 - (34%)
Similarity:	279/526 - (53%)	Gaps:	55/526 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VVALLLIALAVGF--WFVRTRYSYWTRRGIG-SEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKG 65
            ::.|||.:|.:.|  |..|| .|:|.|.|:. ..|  |||...     .:.|:....|.:|:.:.
  Fly     2 LLLLLLGSLTIVFYIWQRRT-LSFWERHGVKYIRP--FPVVGC-----TREFLTAKVPFFEQIQK 58

  Fly    66 -------NGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGH--LFRI 121
                   ...||.|.:|..||.:::.||||.|.::|:.|..|.:|.:..:..:|.| |:  ||..
  Fly    59 FHEAPGFENEPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDAL-GYKNLFFA 122

  Fly   122 DGPKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVI 186
            ..|.||.||.|:||.|||.|:|.|:|.:.::|:.|......|.....   :::.||.:|:|:|:|
  Fly   123 RSPGWRELRTKISPVFTSGKIKQMYPLMVKIGKNLQDSAERLGSGTE---VQVKDLCSRFTTDLI 184

  Fly   187 GRCAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIESFPEVARFLRMRQIHQDITDFYVG 251
            ...|||||.|.|::.::||....|..||......:....|...|.:|...|::...::.|.|...
  Fly   185 ATIAFGVEANALQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMIPALASLARVKLFSRETTKFIRS 249

  Fly   252 IVRETVKQREEQGIVRSDFMNLLIEMKQRG---------ELTIEEMAAQAFIFFAAGFDTSASTL 307
            .|...:|:||..|..|:|.:::|:.:|:..         |:.::.:.|||.:|..|||:|||||:
  Fly   250 SVNYVLKERERTGEKRNDLIDILLALKREAAANPGKMSKEVDLDYLVAQAAVFQTAGFETSASTM 314

  Fly   308 GFALYELAKQPALQAKLREEI-----DQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQL 367
            ...||||||..|||.:||:||     |:      ...:|:.:||:.|:..|:.||||||||:..:
  Fly   315 TMTLYELAKNEALQDRLRQEIVDFFGDE------DHISYERIQEMPYLSQVVNETLRKYPIVGYI 373

  Fly   368 TRISRHLYAAKGDRHFYIEP--------GQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQR 424
            .|....  .|:|:| |.:||        |..:.:....:|.||..:|:|.|:.||||.:......
  Fly   374 ERECSQ--PAEGER-FTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNL 435

  Fly   425 PTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYL 489
            ...|::|||.|||||||||.|.:|:.:|||.:|||..|..|.:|..|||:..::.::.....|.|
  Fly   436 NMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWAPTSPVMASKRDIIL 500

  Fly   490 KVQQLS 495
            :|:::|
  Fly   501 RVEKVS 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	165/486 (34%)
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	164/486 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461131
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900