DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a22 and Cyp4e3

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	133/566 - (23%)
Similarity:	224/566 - (39%)	Gaps:	119/566 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LDVVALLLIALAVGFWFVRTRYSYWTRRGIGSE---PARFPV-GNMEGFRKNKHFIDIVTPI--- 59
            |.|:|||::.|....:|.|....   ||.:..|   |...|: ||.....||.  .:|::..
  Fly     3 LAVLALLVLPLITLVYFERKASQ---RRQLLKEFNGPTPVPILGNANRIGKNP--AEILSTFFDW 62

  Fly    60 -YEKFKGNGAPFAGF---FMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGH-LF 119
             |:..|.|...:.|:   .:|..|..|  :..|..|.|||....::   :.|     |..|| |.
  Fly    63 WYDYGKDNFLFWIGYSSHIVMTNPKQL--EYILNSQQLIQKSTIYD---LLH-----PWLGHGLL 117

  Fly   120 RIDGPKWRPLRQKMSPTF--------------TSAKMKYMFPTVCEVGEELTQVCGELADNAMCG 170
            ...|.||...|:.::|:|              .|||.             :||:....|.:.:..
  Fly   118 TSFGSKWHKHRKMITPSFHFNILQDFHEVMNENSAKF-------------MTQLKKASAGDTIID 169

  Fly   171 ILEIGDLMARYTSDVIGRCAFGVECNGLRNPEAEFAIMGR--------RAFSERRHCKLVDGFIE 227
            ..|..:.:   |.|||...|.||..|.:...::......|        |||...:....|.....
  Fly   170 FQEHANYL---TLDVICDTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTP 231

  Fly   228 SFPEVARFLRMRQIHQDITDFYVGIVRETV--------KQREEQGIVRSD--FMNLLIEMKQRGE 282
            .|....:.|:..|      ||...|:.:.|        |:..:..:.|..  |::.|:.....|.
  Fly   232 EFSAYQKTLKTLQ------DFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTIDGR 290

  Fly   283 -LTIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQAKL-REEIDQALRLHNGEFTYDSMQ 345
             ||.:|:..:...|...|.||:.|.:.|::|.|::.|.:|.|| ||:.:......|...::..:.
  Fly   291 PLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIA 355

  Fly   346 ELRYMELVIAETLRKYPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHK 410
            :::|::|.|.|..|.||.:|.:.|.....|...|.   .:..|..|.:.:..:.::..::.:||.
  Fly   356 KMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDINGS---IVPKGTTLNLALILLGYNDRIFKDPHH 417

  Fly   411 FIPERFLADQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIE-- 473
            |.||||..::.|   ...:|||..|||||||.:|..::....:..::|:  |.|.|..|..:.
  Fly   418 FRPERFEEEKPA---PFEYLPFSAGPRNCIGQKFALLELKTVISKVVRS--FEVLPAVDELVSTD 477

  Fly   474 --------------------------FLKSNILLCPANGIYLKVQQ 493
                                      .|.:.:.|...||::|::::
  Fly   478 GRLNTYLGLAPDEKLKREAGRHKYDPILSAVLTLKSDNGLHLRLRE 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	122/526 (23%)
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	115/474 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910