Protein Alignment Cyp6a22 and CYP27C1

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_001354431.1
• Gene: CYP27C1 / 339761
• HGNCID: 33480
• Length: 537
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 117/520 - (22%)
• Similarity: 200/520 - (38%)
• Gaps: 109/520 - (20%)

  Fly    29 RGIGSEPARFPVGNM------EGFRK-----NKHFIDIVTPIYEK-FKGNGAPFAGFFMMLRPVV 81
            |.:.:.|....:.|:      :||.:     .||     |..|.| ||.:..|        :.||
Human    64 RSLAAMPGPRTLANLAEFFCRDGFSRIHEIQQKH-----TREYGKIFKSHFGP--------QFVV 115

  Fly    82 LVTDLELAKQIL-----IQDFANFEDRGMYHNERDDPLTGHLFRIDGPKWRPLRQKMSPTFTSAK 141
            .:.|.::..|:|     ....||.|....|.:.| ...|| |...:|.:|..:|..:.......|
Human   116 SIADRDMVAQVLRAEGAAPQRANMESWREYRDLR-GRATG-LISAEGEQWLKMRSVLRQRILKPK 178

  Fly   142 MKYMFPTVCEVGEELTQVCGE-------LADNAMCG--ILEIGDLMARYTSDVIGRCAFGVECNG 197
                  .|.....|:.||..:       |...|..|  :..:.||..:|:.:.:....:......
Human   179 ------DVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGC 237

  Fly   198 LRNP------------EAEFAIMGRRAFSE--------------RRHCKLVDGFIESFPEVARFL 236
            |.|.            |..|::.....::.              |..|:..||          ..
Human   238 LENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDG----------LF 292

  Fly   237 RMRQIHQD--ITDFYVGIVRETVKQREEQGIVRSDFMNLLIEMKQRGELTIEEMAAQAFIFFAAG 299
            :..|||.|  :.|....:.|   .:|...|::...|::        ..||::|:.|.......||
Human   293 KFSQIHVDNKLRDIQYQMDR---GRRVSGGLLTYLFLS--------QALTLQEIYANVTEMLLAG 346

  Fly   300 FDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELV---IAETLRKY 361
            .||::.||.:.:|.||:.|.:|..:..||.:.|    ||....:..::..:.||   :.||||.:
Human   347 VDTTSFTLSWTVYLLARHPEVQQTVYREIVKNL----GERHVPTAADVPKVPLVRALLKETLRLF 407

  Fly   362 PILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFL-ADQLAQRP 425
            |:||...|:::......|   :.|..|..|.:..|...:....:|...:|.|||:| ...|.:..
Human   408 PVLPGNGRVTQEDLVIGG---YLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVD 469

  Fly   426 TAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLK 490
            ....:|||.|.|:|||.|..:::..:.::.||:  ||.:...:.......|::.||.|...|:::
Human   470 NFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQ--HFEIKTSSQTNAVHAKTHGLLTPGGPIHVR 532

  Fly   491  490
            Human   533  532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	104/467 (22%)
CYP27C1	NP_001354431.1	CYP27C1	98..530	CDD:410740	109/477 (23%)