Protein Alignment Cyp6a22 and Cyp3a44

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_796354.1
• Gene: Cyp3a44 / 337924
• MGIID: 2449818
• Length: 504
• Species: Mus musculus
• Alignment Length: 512
• Identity: 159/512 - (31%)
• Similarity: 254/512 - (49%)
• Gaps: 48/512 - (9%)

  Fly     2 LDVVALLLIALAVGFWFVRTRYSYWTRRGI-GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKG 65
            ||.:.||.|.|.:.:.:....:..:.::|| |.:|..| :|.:..:.......|:  ..|||:
Mouse     9 LDTLVLLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPF-LGTVLNYYTGIWKFDM--ECYEKY-- 68

  Fly    66 NGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFRI----DGPKW 126
             |..: |.|....|::::||.|..|.:|::|..:     ::.|.|:....|.:.:.    ...:|
Mouse    69 -GKTW-GLFDGQTPLLVITDPETIKNVLVKDCLS-----VFTNRREFGPVGIMSKAISISKDEEW 126

  Fly   127 RPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGRCAF 191
            :..|..:||||||.::|.|||.:.:.|:.|.:...:.|:..|  .:.:.|::..|:.|||...:|
Mouse   127 KRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEAEKGM--PVAMKDVLGAYSMDVITSTSF 189

  Fly   192 GVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGF------IESFP---EVARFLRMRQIHQDITD 247
            ||..:.|.|||..|.       .|.:....||.|      :..||   .|...|.:.....|..:
Mouse   190 GVNVDSLNNPEDPFV-------EEAKKFLRVDFFDPLLFSVVLFPLLTPVYEMLNICMFPNDSIE 247

  Fly   248 FYVGIVRETVKQR-EEQGIVRSDFMNLLIEMKQRGE-------LTIEEMAAQAFIFFAAGFDTSA 304
            |:...|....:.| :.....|.||:.|::......:       .:..|:..|:.||.:||::|::
Mouse   248 FFKKFVDRMQESRLDSNQKHRVDFLQLMMNSHNNSKDKDSHKAFSNMEITVQSIIFISAGYETTS 312

  Fly   305 STLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTR 369
            |||.|.||.||..|.:|.||:.|||:||. :....|.|::.|:.|:::|:.||||.|||:.:|.|
Mouse   313 STLSFTLYCLATHPDIQKKLQAEIDKALP-NKATPTCDTVMEMEYLDMVLNETLRLYPIVTRLER 376

  Fly   370 ISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFGD 434
            :.:......|   .||..|.|::||.|.:||||..:|:|.:|.||||..:.........:||||.
Mouse   377 VCKKDVELNG---VYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKENKGSIDPYVYLPFGI 438

  Fly   435 GPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKV 491
            ||||||||||..|...:.:..:|:||.|..|..|...::..:..||. |...|.|||
Mouse   439 GPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPLKLSRQGILQ-PEKPIVLKV 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	139/442 (31%)
Cyp3a44	NP_796354.1	CYP3A	67..493	CDD:410743	141/448 (31%)