DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp309a2

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	137/507 - (27%)
Similarity:	244/507 - (48%)	Gaps:	40/507 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLDVVALLLIALAV--GFWFVRTRYSYWTRRGIGSEPARFPVGNMEGF--RKNKHFIDIVTPIYE 61
            :|..:||:|:.|.|  .:.::...:.||.:||:.:......:|...|.  ||:....| |..||:
  Fly    34 ILASLALILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFD-VQKIYD 97

  Fly    62 KFKGNGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFED--RGMY--HNERDDPLTGHLFRID 122
            |:||.... .|.|:..:|.:||.|.|||.::|:.:|..::|  :..|  |.:.|.....:.|...
  Fly    98 KYKGKHRA-VGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPFWAS 161

  Fly   123 GPKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQ-VCGELADNAMCGILEIGDLMARYTSDVI 186
            |..||.||.......:.::::..:....:.|:.||: :..::|:..  .|||..||..|||:.|:
  Fly   162 GQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKN--NILETRDLCFRYTAHVM 224

  Fly   187 GRCAFGVECNGLRNPEAEFAIMGRRAFSERRHC-KLVDGFIESF--PEVARFLRMRQIHQDITDF 248
            ....:|::...|..|..:...:...|.....:. .::..|:.:.  |.....||.|...::..:|
  Fly   225 ADFIWGIDAGTLTRPMEQPNKVQEMASKWTSYAFYMLTLFMATIVAPCSRLLLRFRFYPKETDEF 289

  Fly   249 YVGIVRETVKQREEQG-IVRSDFMNLLIEMKQRGELTIEEMAAQAFIFFAAGFDTSASTLGFALY 312
            :..:.:|:::.|.:.| ..|:|:::.|::::.:.:.|.:::...|......|:|||.:.|..|||
  Fly   290 FSNLTKESIELRLKAGDSTRTDYLSHLLQLRDQKQATHDDLVGHALTVMLDGYDTSGTALLHALY 354

  Fly   313 ELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTRISR--HLY 375
            .||:.||:|.|||.||...:.... ...::.:..|:|:|.||.|:||...::||.|::..  .:.
  Fly   355 YLAENPAVQQKLRVEILSCMASEK-SLDFEKLSSLQYLEQVIYESLRLSSLIPQYTKVCTLPTVI 418

  Fly   376 AAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERF---LADQLAQRPTAAWLPFGDGPR 437
            .....:...:|.|..::||.|..|||...:|||..|.||||   ...:|.::  ..:|||.||||
  Fly   419 RLSESKSLDVEVGMTIMIPNYQFHHDKQYFPEPEAFKPERFDNGAYQELMRK--GIFLPFSDGPR 481

  Fly   438 NCIGMRFGKMQTTIGLVSLLRNFH---------------FSVCPRTDPKIEF 474
            .|:|:....:.....||.:|.||.               |.|..:.|..:|:
  Fly   482 ICMGVPLAMLTLKSALVHILSNFQVVRGRDRLIPKGDSGFGVVLQGDVNLEY 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	127/471 (27%)
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	125/462 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460999
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900