DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp309a1

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	144/491 - (29%)
Similarity:	236/491 - (48%)	Gaps:	49/491 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLDVVALLL----IALAVGFWFVRTRYSYWTRRG-IGSEPARFPVGNMEG--FRKNKHFIDIVTP 58
            |..:|.|.|    :|.||.::::...:.||.:|| :.:||... :|:..|  ..|::..|..|..
  Fly     1 MFTLVGLCLTIVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTI-LGSYPGILINKSRSLILDVQD 64

  Fly    59 IYEKFKGNGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFED----RGMYHNERDDPLTGHLF 119
            :|.|:|..... .|.|:..:|.:||.|..||.:||:..|::|.|    ..:.||..|..:.|..|
  Fly    65 VYNKYKDKYRT-VGTFITRQPQLLVLDPALAHEILVDKFSHFRDTITSSFVGHNPDDKYVAGSPF 128

  Fly   120 RIDGPKWRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSD 184
            ...|.||:.||.:.....|.:::|..:....:.|.:|.:.. |.|......|:|..||..|:|::
  Fly   129 FSAGDKWKRLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYI-ERARREQGDIIETRDLAYRFTAN 192

  Fly   185 VIGRCAFGVECNGLRNPEAEFAIMGR-------RAFSE--RRHCKLVDGFIESFPEVARFLRMRQ 240
            .:....:|::...|.....|.....:       .|||.  |.:..||..|      |.:...||.
  Fly   193 AMADFIWGIDAGSLSGKVGEIGDFQKTSTDWSAHAFSSMIRFNKTLVAIF------VRKLFSMRF 251

  Fly   241 IHQDITDFYVGIVRETVKQRE-EQGIVRSDFMNLLIEMKQRGELTIEEMAAQAFIFFAAGFDTSA 304
            ..:...:|::.:.::.|..|: ..|..|:|:::.||:::|||. :|.:....|......||:||.
  Fly   252 FTKATDEFFLRLTQDAVNLRQGGSGEGRTDYLSHLIQLQQRGN-SIHDSVGHALTVHLDGFETSG 315

  Fly   305 STLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRK-------YP 362
            :.|...||.|::....|.|||.||.:|| ...|:.:||.:..|.|::....|:||.       ..
  Fly   316 AVLYHMLYSLSEHHEEQEKLRSEILEAL-ASEGQISYDQINNLPYLDQCFNESLRLTTPIGFFMR 379

  Fly   363 ILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERF---LADQLAQR 424
            |..:.|:|:     ...|:...:|||..:::|.|..|||..:|||..:|.|:||   .|..|.:|
  Fly   380 ICTKPTQIN-----LGDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRFENGAASVLTKR 439

  Fly   425 PTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNF 460
              ..:||||||||.|:|||.|::.....:|.:|.|:
  Fly   440 --GCFLPFGDGPRICLGMRVGQLSVKTAIVHILSNY 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	132/452 (29%)
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	130/442 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460987
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.000