DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	508	Identity:	151/508 - (29%)
Similarity:	244/508 - (48%)	Gaps:	45/508 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VVALLLIALAVGFWFVRTRYSYWTRRGI-GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKGNG 67
            ||.::.:.|..|.|    .:.::.:.|| |..|..| ||....:.|.....||     |..|..|
Zfish    14 VVLVITLLLIYGVW----PHGFFKKLGIPGPRPLPF-VGTALSYSKGICNFDI-----ECSKKYG 68

  Fly    68 APFAGFFMMLRPVVLVTDLELAKQILIQD-FANFEDRGMYHNERDDPLTGHLFRIDGPKWRPLRQ 131
            ..: |.:....|::||||||:.|.||::| ::.|.:|...:.:...|....:..:...:||.:|.
Zfish    69 KVW-GIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNRRNMNPDLVGPFADGITLVKDERWRRIRS 132

  Fly   132 KMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGRCAFGVECN 196
            .:||.|||.::|.:||......:...:...:...|..   |:|.|::|.|:.||:...:|.|:.:
Zfish   133 SLSPYFTSGRLKEIFPIAMTHADRFIKNMEKKDPNLP---LKIKDVVAPYSLDVVASSSFSVDFD 194

  Fly   197 GLRNPEAEFAIMGRRAFSERRHCKLVDGFIESF-PEVARFLRMRQI---HQDITDFYVGIVRETV 257
            .:.||:..|....:..|:......|.  .:.:| |..|..|....|   .:..||||...:|: :
Zfish   195 SINNPDDPFVTSIKSFFNINPLSPLF--LLLAFCPSAANLLAKMGISVFSRSTTDFYYKALRK-I 256

  Fly   258 KQREEQGIVRSDFMNLLI--------------EMKQRGELTIEEMAAQAFIFFAAGFDTSASTLG 308
            |....:...|.||:.|:|              |...:| ||..|:.:|:|||...|::|:::||.
Zfish   257 KDEHNESNGRVDFLKLMIQNQIPDDQVKDTASEQPVKG-LTDHEILSQSFIFILGGYETTSTTLS 320

  Fly   309 FALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTRISRH 373
            :.||.||..|....||.||||:...| :...|||::..:.|:|:.|.|::|.:|..|:|.|:.:.
Zfish   321 YLLYNLATNPDCLEKLVEEIDKNFPL-DIPITYDALMRMDYLEMAIHESMRVFPAGPRLERVCKK 384

  Fly   374 LYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAAWLPFGDGPRN 438
            .....|   ..|....::.||:|.:..||.|:..|::|.||||..:...:....|::|||.||||
Zfish   385 TVEING---ITIPKNTLVGIPLYVLSRDPDLWESPNEFKPERFSPESKTEINQCAFMPFGLGPRN 446

  Fly   439 CIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKV 491
            ||||||..|...:.:|.||:.:....|..|...::.   |....|...|.||:
Zfish   447 CIGMRFALMMMKLLVVKLLQKYTVETCKETQIPVQL---NFFFQPKVPITLKL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	142/474 (30%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	143/478 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.910