DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a22 and Cyp28c1

DIOPT Version :9

Sequence 1:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	138/492 - (28%)
Similarity:	235/492 - (47%)	Gaps:	40/492 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLIALAVG--FWFVRTRYSYWTRRGIGSEPARFPV----GNMEGFRKNKHFIDIVTPIYEKFKG 65
            ||.||..:|  :.|:.:.:.:|.|||: :||...|:    .||  ....:||...:..||..::
  Fly     6 LLGIATLLGAIYAFLVSNFGHWRRRGV-TEPRALPLFGSFPNM--IWPRQHFTMDMRDIYMHYR- 66

  Fly    66 NGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRG---MYHNERDDPLTGHLFRIDGPKWR 127
            |...:.|.:::..|.:||.:..|..:|.:..|::||:..   |....:|..:..:.|.::|.:||
  Fly    67 NTHSYVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLVALNPFVLEGEEWR 131

  Fly   128 PLRQKMSPTFTSAKMK---YMFPTVCEVGEELTQVCGELADNAMCG-ILEIGDLMARYTSDVIGR 188
            ..|...|...|:.:::   .:...||      ..:|..:|..:..| .|:..||..|:|.:.:..
  Fly   132 HQRAVFSTLLTNGRIRTTHAIMQRVC------LDLCQFIAIKSAGGKDLDCIDLGLRFTGESLFD 190

  Fly   189 CAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIESFPEVARFLRMRQIHQDITDFYVGIV 253
            |..|::.....:.............:|.|...:.......||.:.|:||.:...:....||..::
  Fly   191 CVLGIQARTFTDNPLPVVRQNHEMSAENRGLAIAGAVHGLFPNLPRWLRPKVFPRSHDRFYGQMI 255

  Fly   254 RETVKQREEQGIVRSDFMNLLIEMKQRGELTIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQP 318
            .|.::.|..:...|:||:|.|:||::..:|:.|:||:.|..|...|.||:::::...|..|.:.|
  Fly   256 SEALRLRRSKHQERNDFINHLLEMQRELDLSEEDMASHAMTFMFDGLDTTSNSIAHCLLLLGRNP 320

  Fly   319 ALQAKLREEIDQALRLHN-GEF--TYDSMQELRYMELVIAETLRKYPILPQLTRISRHLYAAKGD 380
            ..|.:|.||    |:|.| |.:  ..|::.:|.|:.....|:||.||.....::.....|..:|.
  Fly   321 DCQRRLYEE----LQLVNPGGYLPDLDALIDLPYLSACFNESLRIYPAGGWASKTCTKEYELRGS 381

  Fly   381 RH---FYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQ-RPTAAWLPFGDGPRNCIG 441
            .|   ..:.||..:::|:|.:|:||.|||||..|.|||||...|.. :....:|.||:|||.|:|
  Fly   382 HHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGIFLGFGNGPRQCVG 446

  Fly   442 MRFGKMQTTIGLVSLLRNFHFSVCPRT------DPKI 472
            ||.|.......|.::::.|...|.|||      ||.|
  Fly   447 MRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELDPLI 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	127/462 (27%)
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	127/462 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460927
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900