Protein Alignment Cyp6a22 and Cyp4a12a

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_803125.2
• Gene: Cyp4a12a / 277753
• MGIID: 88612
• Length: 508
• Species: Mus musculus
• Alignment Length: 539
• Identity: 132/539 - (24%)
• Similarity: 233/539 - (43%)
• Gaps: 103/539 - (19%)

  Fly     4 VVALLLIALAVGFWFVRTRYSYWTRRGIGSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKGNGA 68
            |::|||:.......::..::...:.:...|.|:.:..|:.  ..|::...||:|.|  |...:..
Mouse    24 VLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHK--ILKDQDLQDILTRI--KNFPSAC 84

  Fly    69 PFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFR------------I 121
            |...:...:|  :.|.|.:..|.||               .|.||.....:|            :
Mouse    85 PQWLWGSKVR--IQVYDPDYMKLIL---------------GRSDPKANGSYRFLAPWIGRGLLML 132

  Fly   122 DGPKWRPLRQKMSPTFTSAKMK----YMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYT 182
            ||..|...|:.::|.|....:|    .|..:|..:.::..|:.|:  |:.    |||...:...|
Mouse   133 DGQTWFQHRRMLTPAFHYDILKPYTEIMADSVRVMLDKWEQIVGQ--DST----LEIFRHITLMT 191

  Fly   183 SDVIGRCAFGVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIESFPEVARFLRMRQI-HQ--- 243
            .|.|.:|||..|.:               ...:|::...:.. :|...::. |.|:|.| ||
Mouse   192 LDTIMKCAFSHEGS---------------VQLDRKYKSYIQA-VEDLNDLV-FSRVRNIFHQNDI 239

  Fly   244 -------------------DITDFYVGIVRETVKQREEQGIV----RSDFMNLLI--EMKQRGEL 283
                               |.||..:...|..::..||...:    |.||:::|:  .|:....|
Mouse   240 IYRVSSNGCKANSACKLAHDHTDQVIKSRRIQLQDEEELEKLKKKRRLDFLDILLFARMENGKSL 304

  Fly   284 TIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELR 348
            :.:::.|:...|...|.||:||.:.:..|.||..|..|.:.|:|| |:|.......|::.:.::.
Mouse   305 SDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEI-QSLLGDGTSITWNDLDKMP 368

  Fly   349 YMELVIAETLRKYPILPQLTR-ISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFI 412
            |..:.|.|.||.||.:|.::| :|..:....|..   :..|..:::..||:||:|.::|.|..|.
Mouse   369 YTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRS---LPKGIHVMLSFYGLHHNPTVWPNPEVFD 430

  Fly   413 PERFLADQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGL-VSLLRNFHFSVCPRTDP-KIEFL 475
            |.||...  :.|.:.::|||..|.|||||.:|...:..:.: ::|||   |.:.|  || ::...
Mouse   431 PSRFAPG--SSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLR---FELLP--DPTRVPIP 488

  Fly   476 KSNILLCPANGIYLKVQQL 494
            ...|:|...|||:|.:::|
Mouse   489 IPRIVLKSKNGIHLHLKKL 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	116/469 (25%)
Cyp4a12a	NP_803125.2	CYP4B-like	70..503	CDD:410771	122/485 (25%)