Protein Alignment Cyp6a22 and Cyp3a2

DIOPT Version :10

• Sequence 1: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: XP_063127162.1
• Gene: Cyp3a2 / 266682
• RGDID: 708379
• Length: 505
• Species: Rattus norvegicus
• Alignment Length: 526
• Identity: 155/526 - (29%)
• Similarity: 244/526 - (46%)
• Gaps: 75/526 - (14%)

  Fly     2 LDVVALLLIALAVGFWFVRTRYSYWTRRGI-GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKG 65
            |:...||.:.|.:.:.....|:..:.::|| |.:|..| :|.:..:.|.....|:  ..|:|:
  Rat     9 LETWVLLAVILVLLYRLGTHRHGIFKKQGIPGPKPLPF-LGTVLNYYKGLGRFDM--ECYKKY-- 68

  Fly    66 NGAPFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFR----IDGPKW 126
              ....|.|....||..:.|.|:.|.:|::     |...::.|.||....|.:.:    ....:|
  Rat    69 --GKIWGLFDGQTPVFAIMDTEMIKNVLVK-----ECFSVFTNRRDFGPVGIMGKAVSVAKDEEW 126

  Fly   127 RPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGRCAF 191
            :..|..:||||||.::|.|||.:.:.|:.|.:...:.|:...  .:.:..:...|:.|||...:|
  Rat   127 KRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQEAETGK--PVTMKKVFGAYSMDVITSTSF 189

  Fly   192 GVECNGLRNPEAEFAIMGRRAFSERRHCKLVDGFIESFPEVARF--------------------- 235
            ||..:.|.||:                    |.|:|...::.||
  Rat   190 GVNVDSLNNPK--------------------DPFVEKTKKLLRFDFFDPLFLSVVLFPFLTPIYE 234

  Fly   236 -LRMRQIHQDITDFYVGIVRETVKQR--EEQGIVRSDFMNLLIEMKQRGE-------LTIEEMAA 290
             |.:....:|...|:...|....:.|  .:..:.|.||:.|::......:       |:..|:.|
  Rat   235 MLNICMFPKDSIAFFQKFVHRIKETRLDSKHKVHRVDFLQLMLNAHNNSKDEVSHKALSDVEIIA 299

  Fly   291 QAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIA 355
            |:.||..||::|::|||.|.||.||..|.:|.||:||||.||. .....|||.:.|:.|:::|:.
  Rat   300 QSVIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALP-SKAPPTYDIVMEMEYLDMVLN 363

  Fly   356 ETLRKYPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQ 420
            ||||.|||..:|.|:.:......|   .:|..|.::.||.|.:||||..:|:|.:|.||||..:.
  Rat   364 ETLRLYPIGNRLERVCKKDIELDG---LFIPKGSVVTIPTYALHHDPQHWPKPEEFHPERFSKEN 425

  Fly   421 LAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPAN 485
            ........:||||:||||||||||..|...:.|..:|:||.|..|..|...:: |....:|.|..
  Rat   426 KGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLK-LSRQAILEPEK 489

  Fly   486 GIYLKV 491
            .|.|||
  Rat   490 PIVLKV 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	136/456 (30%)
Cyp3a2	XP_063127162.1	None